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HRG Inhibits Tumor ...
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Rolny, CharlotteUppsala universitet,Cancer och vaskulärbiologi,Forskargrupp Rolny
(author)
HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PIGF
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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Elsevier BV,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-149047
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149047URI
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https://doi.org/10.1016/j.ccr.2010.11.009DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De två första författarna delar förstaförfattarskapet.De två sista författarna delar sistaförfattarskapet.
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Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polarization away from the M2- to a tumor-inhibiting M1-like phenotype, HRG promotes antitumor immune responses and vessel normalization, effects known to decrease tumor growth and metastasis and to enhance chemotherapy. Skewing of TAM polarization by HAG relies substantially on downregulation of placental growth factor (PIGF). Besides unveiling an important role for TAM polarization in tumor vessel abnormalization, and its regulation by HRG/PIGF, these findings offer therapeutic opportunities for anticancer and antiangiogenic treatment.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Mazzone, Massimiliano
(author)
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Tugues, SòniaUppsala universitet,Cancer och vaskulärbiologi,Forskargrupp Claesson-Welsh
(author)
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Laoui, Damya
(author)
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Johansson, IrjaUppsala universitet,Institutionen för genetik och patologi
(author)
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Coulon, Cathy
(author)
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Squadrito, Mario Leonardo
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Segura, Inmaculada
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Li, XiujuanUppsala universitet,Cancer och vaskulärbiologi,Forskargrupp Claesson-Welsh(Swepub:uu)xilix168
(author)
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Knevels, Ellen
(author)
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Costa, Sandra
(author)
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Vinckier, Stefan
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Dresselaer, Tom
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Åkerud, PeterUppsala universitet,Kolorektalkirurgi(Swepub:uu)petak537
(author)
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De Mol, Maria
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Salomäki, HenriikkaUppsala universitet,Institutionen för genetik och patologi
(author)
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Phillipson, MiaUppsala universitet,Integrativ Fysiologi(Swepub:uu)mjo07958
(author)
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Wyns, Sabine
(author)
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Larsson, ErikUppsala universitet,Molekylär och morfologisk patologi,Forskargrupp Larsson(Swepub:uu)eriklars
(author)
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Buysschaert, Ian
(author)
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Botling, JohanUppsala universitet,Molekylär och morfologisk patologi,Forskargrupp Botling(Swepub:uu)johanbot
(author)
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Himmelreich, Uwe
(author)
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Van Ginderachter, Jo A.
(author)
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De Palma, Michele
(author)
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Dewerchin, Mieke
(author)
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Claesson-Welsh, LenaUppsala universitet,Cancer och vaskulärbiologi,Forskargrupp Claesson-Welsh(Swepub:uu)lcl04207
(author)
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Carmeliet, Peter
(author)
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Uppsala universitetCancer och vaskulärbiologi
(creator_code:org_t)
Related titles
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In:Cancer Cell: Elsevier BV19:1, s. 31-441535-61081878-3686
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Rolny, Charlotte
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Mazzone, Massimi ...
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Tugues, Sònia
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Laoui, Damya
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Johansson, Irja
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Coulon, Cathy
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Squadrito, Mario ...
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Segura, Inmacula ...
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Li, Xiujuan
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Knevels, Ellen
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Costa, Sandra
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Vinckier, Stefan
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Dresselaer, Tom
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Åkerud, Peter
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De Mol, Maria
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Salomäki, Henrii ...
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Phillipson, Mia
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Wyns, Sabine
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Larsson, Erik
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Buysschaert, Ian
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Botling, Johan
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Himmelreich, Uwe
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Van Ginderachter ...
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De Palma, Michel ...
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Dewerchin, Mieke
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Claesson-Welsh, ...
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Carmeliet, Peter
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Cancer Cell
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Uppsala University