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Plasma TIMP-1 level...
Plasma TIMP-1 levels and treatment outcome in patients treated with XELOX for metastatic colorectal cancer
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Frederiksen, C. (author)
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Qvortrup, C. (author)
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Christensen, I. J. (author)
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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- Berglund, Åke (author)
- Uppsala universitet,Enheten för onkologi
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Jensen, B. V. (author)
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Nielsen, S. E. (author)
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Keldsen, N. (author)
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Nielsen, H. J. (author)
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Brunner, N. (author)
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Pfeiffer, P. (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 22:2, s. 369-375
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background: The aim was to evaluate the association between plasma tissue inhibitor of metalloproteinase-1 (TIMP-1) and serum carcinoembryonic antigen (CEA) levels and outcome in patients with metastatic colorectal cancer (mCRC) receiving XELOX (combination chemotherapy with capecitabine and oxaliplatin) as first-line treatment. Patients and methods: One hundred and twenty patients were included. Blood samples were collected before treatment and 3 weeks later before the next treatment cycle. Plasma TIMP-1 and serum CEA levels were correlated to treatment outcome. Results: No significant associations between baseline TIMP-1 or CEA levels and best response to treatment or progression-free survival (PFS) could be demonstrated. In contrast, high baseline plasma TIMP-1 levels were associated with poor overall survival (OS), P = 0.008, hazard ratio (HR) = 1.80 [95% confidence interval (CI): 1.17-2.78]. Furthermore, increase in TIMP-1 levels from baseline to immediately before the second cycle of chemotherapy had a significant negative effect on survival (P = 0.03, HR = 1.30, 95% CI: 1.02-1.65) while a decrease in TIMP-1 was significantly associated with a higher objective response rate (P = 0.03). Conclusions: Both high baseline and subsequent increase in TIMP-1 levels were associated with shorter OS in patients with mCRC receiving XELOX as first-line treatment, whereas baseline TIMP-1 levels were not associated with response or PFS following XELOX treatment.
Keyword
- biomarkers
- metastatic colorectal cancer
- overall survival
- progression-free survival
- response
- XELOX
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Frederiksen, C.
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Qvortrup, C.
-
Christensen, I. ...
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Glimelius, Bengt
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Berglund, Åke
-
Jensen, B. V.
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show more...
-
Nielsen, S. E.
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Keldsen, N.
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Nielsen, H. J.
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Brunner, N.
-
Pfeiffer, P.
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show less...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Uppsala University
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Karolinska Institutet