Search: onr:"swepub:oai:DiVA.org:uu-149402" >
Mast cell infiltrat...
Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma
-
- Molin, Daniel (author)
- Uppsala universitet,Enheten för onkologi,Molekylär och morfologisk patologi
-
- Edström, Annika (author)
- Uppsala universitet,Enheten för onkologi
-
- Glimelius, Ingrid (author)
- Uppsala universitet,Enheten för onkologi
-
show more...
-
- Glimelius, Bengt (author)
- Karolinska Institutet,Uppsala universitet,Enheten för onkologi
-
- Nilsson, Gunnar (author)
- Uppsala universitet,Molekylär och morfologisk patologi
-
- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi
-
- Enblad, Gunilla (author)
- Uppsala universitet,Enheten för onkologi
-
show less...
-
(creator_code:org_t)
- 2002-10-02
- 2002
- English.
-
In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 119:1, s. 122-124
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Hodgkin's lymphoma (HL) is characterized by a few Hodgkin, Reed-Sternberg cells (HRS) surrounded by benign cells. We recently reported that mast cells were the predominant CD30L-positive cells in HL tumours, and that they activate HRS in vitro through CD30L-CD30 interaction. Here, we investigated the clinical importance of mast cell infiltration in the tumours of 123 patients. Tumour specimens were stained with a mast-cell-specific antibody that detects tryptase. Mast cells were detected in virtually every case and increasing numbers of mast cells correlated to nodular sclerosis histology (P = 0.008). Patients with higher mast cell infiltration had a worse relapse-free survival (P = 0.01).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database