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Prognostic but not ...
Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma
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- Paulsson, Janna (author)
- Karolinska Institutet
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- Lindh, Maja Bradic (author)
- Karolinska Institutet
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- Jarvius, Malin (author)
- Uppsala universitet,Molekylära verktyg,Forskargrupp Landegren
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Puputti, Marjut (author)
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- Nistér, Monica (author)
- Karolinska Institutet
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Nupponen, Nina N. (author)
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Paulus, Werner (author)
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- Söderberg, Ola (author)
- Uppsala universitet,Molekylära verktyg,Forskargrupp Landegren
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Dresemann, Gregor (author)
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von Deimling, Andreas (author)
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Joensuu, Heikki (author)
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- Östman, Arne (author)
- Karolinska Institutet
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Hasselblatt, Martin (author)
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(creator_code:org_t)
- 2010-06-29
- 2011
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 128:8, s. 1981-1988
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Platelet-derived growth factor receptor (PDGFR) signaling has been implicated in the pathogenesis of glioblastomas and represents a target for the tyrosine kinase inhibitor imatinib. To examine the prognostic or predictive role of PDGFRs in recurrent glioblastomas, expression was examined in tumor samples of 101 patients of CSTI571BDE40, a randomized trial comparing hydroxyurea monotherapy and a combination of hydroxyurea and imatinib. Furthermore, PDGFRa phosphorylation was investigated using in situ proximity ligation assay. PDGFRa protein was expressed in 33% of tumors and was associated with male sex, young age, presence of R132H mutated isocitrate dehydrogenase 1 protein and short median survival (142 vs. 187 days, p = 0.028). Tumor PDGFRa phosphorylation was also associated with short survival (p = 0.030). The subset of patients with PDGFRa positive glioblastoma did not have longer survival on treatment with hydroxyurea and imatinib compared with hydroxyurea monotherapy. In conclusion, both PDGFRa protein expression and phosphorylation status had a prognostic role in recurrent glioblastomas but did not define a group that showed benefit from the combination therapy consisting of hydroxyurea and imatinib.
Keyword
- prognosis
- malignant glioma
- imatinib
- hydroxyurea
- platelet-derived growth factor receptor alpha
- IDH1
- phosphorylation
- randomized trial
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Paulsson, Janna
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Lindh, Maja Brad ...
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Jarvius, Malin
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Puputti, Marjut
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Nistér, Monica
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Nupponen, Nina N ...
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show more...
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Paulus, Werner
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Söderberg, Ola
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Dresemann, Grego ...
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von Deimling, An ...
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Joensuu, Heikki
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Östman, Arne
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Hasselblatt, Mar ...
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Uppsala University
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Karolinska Institutet