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Transplantable func...
Transplantable functional islet mass – predictive biomarkers of graft function in islet after kidney transplanted patients
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- Friberg, Andrew S (author)
- Uppsala universitet,Klinisk immunologi,forskargrup Korsgren
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- Lundgren, Torbjörn (author)
- Karolinska Institutet
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- Malm, Helene (author)
- Uppsala universitet,Transplantationskirurgi
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- Felldin, Marie (author)
- Sahlgrenska University Hospital
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- Nilsson, Bo (author)
- Uppsala universitet,Klinisk immunologi
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- Jensson, Trond (author)
- Oslo University Hospital, Rikshospitalet
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- Kyllönen, Lauri (author)
- Helsinki University
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- Tufveson, Gunnar (author)
- Uppsala University Hospital
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- Tibell, Annika (author)
- Karolinska Institutet
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- Korsgren, Olle (author)
- Uppsala universitet,Klinisk immunologi,forskargrup Korsgren
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- The ability to predict clinical function of a specific islet batch released for clinical transplantation using standardized variables remains an elusive goal. Analysis of donor, islet isolation, quality control and recipient variables was undertaken in 110 islet after kidney (IAK) transplants and correlated to the pre- to 28-day posttransplant change in C-peptide to glucose and creatinine ratio (ΔCP/GCr). Using backward multiple regression the variables positively associated to ΔCP/GCr were islet volume transplanted (p<0.001) and glucose stimulated insulin secretion (SI) (p=0.009). Factors negatively associated to ΔCP/GCr were cold ischemia time (CIT) (p=0.002) and total tissue volume (p=0.009). Donor age, donor body mass index, number of retrieved organs from the donor, preservation solution, islet insulin content, body weight of the recipient of the islets had no influence on transplant function. The transplantable functional islet mass (TFIM), accounting for islet volume transplanted, SI, CIT, and total tissue volume explained 39% of the variance of the clinical outcome in the IAK data set. Therefore, the TFIM provides a straightforward and potent tool to guide the decision to utilize a specific islet preparation for clinical transplantation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Islet transplantation
- kidney function
- predict outcome
- transplantable islet mass
- Transplantation surgery
- Transplantationskirurgi
- Medicin
- Medicine
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Friberg, Andrew ...
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Lundgren, Torbjö ...
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Malm, Helene
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Felldin, Marie
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Nilsson, Bo
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Jensson, Trond
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show more...
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Kyllönen, Lauri
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Tufveson, Gunnar
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Tibell, Annika
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Korsgren, Olle
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- By the university
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Uppsala University