Search: onr:"swepub:oai:DiVA.org:uu-150597" >
Potential associati...
Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome
-
- Appel, Silke (author)
- Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
-
- Le Hellard, Stephanie (author)
- Department of Clinical Medicine, University of Bergen, Bergen, Norway
-
- Bruland, Ove (author)
- Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
-
show more...
-
- Brun, Johan G. (author)
- Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
-
- Omdal, Roald (author)
- Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
-
- Kristjansdottir, Gudlaug (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala
-
- Theander, Elke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Rheumatology, Malmö University Hospital, Malmö
-
- Nordmark, Gunnel (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala
-
- Kvarnström, Marika (author)
- Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm
-
- Eriksson, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Njurmedicinska kliniken US
-
- Rönnblom, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala
-
- Wahren-Herlenius, Marie (author)
- Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm
-
- Jonsson, Roland (author)
- Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
-
show less...
-
(creator_code:org_t)
- 2011-03-30
- 2011
- English.
-
In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 70:7, s. 1327-1329
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Background: Primary Sjögren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocrine pathways involving the muscarinic receptor 3 (CHRM3) has been indicated. Objective: To investigate possible genetic divergence in the CHRM3 gene in patients with pSS. Methods: 530 patients with pSS and 532 controls from a combined Swedish and Norwegian cohort were genotyped for 84 single nucleotide polymorphisms (SNPs) distributed throughout CHRM3. Results: Genetic association was observed with five SNPs localised in intron 3 and 4 of CHRM3, the strongest being rs7548522 (minor allele frequency = 0.06, OR=1.93, 95% CI (1.24 to 3.01); p=0.0033). In addition, clinical parameters, including focus score, abnormal Schirmer's test and presence of autoantibodies, were associated with different SNPs in CHRM3. Conclusion: The study demonstrates a novel association of CHRM3 polymorphisms with pSS, suggesting a functional role for CHRM3 and the salivary gland parenchyma in the pathogenesis of pSS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Appel, Silke
-
Le Hellard, Step ...
-
Bruland, Ove
-
Brun, Johan G.
-
Omdal, Roald
-
Kristjansdottir, ...
-
show more...
-
Theander, Elke
-
Nordmark, Gunnel
-
Kvarnström, Mari ...
-
Eriksson, Per
-
Rönnblom, Lars
-
Wahren-Herlenius ...
-
Jonsson, Roland
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Annals of the Rh ...
- By the university
-
Uppsala University
-
Lund University
-
Karolinska Institutet
-
Linköping University