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Dose-tailoring of F...
Dose-tailoring of FEC adjuvant chemotherapy based on leukopenia is feasible and well tolerated. Toxicity and dose intensity in the Scandinavian Breast Group phase 3 adjuvant Trial SBG 2000-1
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Edlund, Per (author)
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Ahlgren, Johan (author)
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Bjerre, Karsten (author)
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Andersson, Michael (author)
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- Bergh, Jonas (author)
- Karolinska Institutet
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Mouridsen, Henning (author)
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- Holmberg, Stig B. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Bengtsson, Nils-Olof (author)
- Umeå universitet,Onkologi
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Jakobsen, Erik (author)
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Moller, Susanne (author)
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- Lindman, Henrik (author)
- Uppsala universitet,Enheten för onkologi
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- Blomqvist, Carl (author)
- Uppsala universitet,Enheten för onkologi
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(creator_code:org_t)
- Informa Healthcare, 2011
- 2011
- English.
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In: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 50:3, s. 329-337
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- The SBG 2000-1 trial is a randomised study that investigates if dose-tailored adjuvant FEC therapy based on the individual's leukocyte nadir value can improve outcome. The study has included 1535 women with medium and high-risk breast cancer. Patients and methods. After a first standard dosed FEC course (5-fluorouracil 600 mg/m(2), epirubicin 60 mg/mg(2) and cyclophosphamide 600 mg/m(2)), patients who did not reach leukopenia grade III or IV were randomised to standard doses (group standard) or doses tailored to achieve grade III leukopenia (group tailored) at courses 2 7. Patients who achieved leukopenia grade III or more after the first course were not randomised but continued on standard doses (group registered). Results. Both planned and actually delivered number of courses (seven) were the same in all three arms. The relative dose intensity was increased by a factor of 1.31 (E 1.22, C 1.43) for patients in the tailored arm compared to the expected on standard dose. Ninety percent of the patients in the tailored arm achieved leukopenia grade III-IV compared with 29% among patients randomised to standard dosed therapy. Dose tailoring was associated with acceptable acute non-haematological toxicity with more total alopecia, nausea, vomiting and fatigue. Conclusion. Dose tailoring according to leukopenia was feasible. It led to an increased dose intensity and was associated with acceptable excess of acute non-haematological toxicity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Edlund, Per
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Ahlgren, Johan
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Bjerre, Karsten
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Andersson, Micha ...
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Bergh, Jonas
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Mouridsen, Henni ...
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show more...
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Holmberg, Stig B ...
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Bengtsson, Nils- ...
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Jakobsen, Erik
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Moller, Susanne
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Lindman, Henrik
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Blomqvist, Carl
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Acta Oncologica
- By the university
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Uppsala University
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Umeå University
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University of Gothenburg
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Karolinska Institutet