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A polyclonal antise...
A polyclonal antiserum against chromogranin A and B : a new sensitive marker for neuroendocrine tumors
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- Eriksson, Barbro (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Arnberg, H (author)
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- Öberg, Kjell (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Hellman, U (author)
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Lundqvist, G (author)
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Wernstedt, C (author)
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Wilander, Erik (author)
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(creator_code:org_t)
- Oxford University Press (OUP), 1990
- 1990
- English.
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In: Acta Endocrinologica. - : Oxford University Press (OUP). - 0001-5598 .- 0804-4643 .- 1479-683X. ; 122:2, s. 145-155
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Chromogranins A, B, and C, proteins that are co-stored and co-released with peptides and amines, have been identified in a variety of neuroendocrine tissues, both normal and neoplastic. We examined the secretion of chromogranin A and chromogranin A + B by hormone-producing tumours in patients with endocrine pancreatic tumours, carcinoid tumours, pheochromocytomas, and small cell lung cancer. The radioimmunoassay determining the plasma concentrations of chromogranin A + B showed a greater sensitivity than that determining chromogranin A alone. All patients with endocrine pancreatic tumours, carcinoids, and pheochromocytomas had increased levels of chromograin A + B, whereas a small number of the patients (5/18 with endocrine pancreatic tumours and with pheochromocytomas) had normal levels of chromogranin A. Also in immunocytochemical stainings, our polyclonal antiserum detecting both chromogranin A and B showed a greater sensitivity than other available antisera against chromogranin A, B and C. We have demonstrated that a polyclonal antiserum against a mixture of chromogranin A and B might be a more sensitive marker than chromogranin A alone for diagnosing neuroendocrine tumours. This is not surprising, since both chromogranins are widely distributed in neuroendocrine cells.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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