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A systematic review...
A systematic review of cost-effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives.
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Verhoef, Talitha I (author)
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Redekop, William K (author)
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Darba, Josep (author)
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Geitona, Mary (author)
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Hughes, Dyfrig A (author)
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Siebert, Uwe (author)
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de Boer, Anthonius (author)
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Maitland-van der Zee, Anke-Hilse (author)
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Barallon, Rita (author)
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Briz, Montserrat (author)
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Daly, Ann (author)
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Haschke-Becher, Elisabeth (author)
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Kamali, Farhad (author)
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Kirchheiner, Julia (author)
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Manolopoulos, Vangelis G (author)
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Pirmohamed, Munir (author)
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Rosendaal, Frits R (author)
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van Schie, Rianne M F (author)
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos
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(creator_code:org_t)
- Future Medicine Ltd, 2010
- 2010
- English.
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In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 11:7, s. 989-1002
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- Anticoagulant therapy with coumarin derivatives is often sub- or supra-therapeutic, resulting in an increased risk of thromboembolic events or hemorrhage, respectively. Pharmacogenetic-guided dosing has been proposed as an effective way of reducing bleeding rates. Clinical trials to confirm the safety, efficacy and effectiveness of this strategy are ongoing, but in addition, it is also necessary to consider the cost-effectiveness of this strategy. This article describes the findings of a systematic review of published cost-effectiveness analyses of pharmacogenetic-guided dosing of coumarin derivatives. Similarities and differences in the approaches used were examined and the quality of the analyses was assessed. The results of the analyses are not sufficient to determine whether or not pharmacogenetic-guided dosing of coumarins is cost effective. More reliable cost-effectiveness estimates need to become available before it is possible to recommend whether or not this strategy should be applied in clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Verhoef, Talitha ...
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Redekop, William ...
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Darba, Josep
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Geitona, Mary
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Hughes, Dyfrig A
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Siebert, Uwe
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show more...
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de Boer, Anthoni ...
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Maitland-van der ...
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Barallon, Rita
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Briz, Montserrat
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Daly, Ann
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Haschke-Becher, ...
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Kamali, Farhad
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Kirchheiner, Jul ...
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Manolopoulos, Va ...
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Pirmohamed, Muni ...
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Rosendaal, Frits ...
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van Schie, Riann ...
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Wadelius, Mia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Pharmacogenomics ...
- By the university
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Uppsala University