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  • Zachariadis, V.Karolinska Institutet (author)

The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia : results from the NOPHO ALL-2000 trial

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-01-18
  • London :Springer Science and Business Media LLC,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-152836
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152836URI
  • https://doi.org/10.1038/leu.2010.318DOI
  • https://lup.lub.lu.se/record/1965535URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40534URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122390234URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The dic(9;20)(p13.2;q11.2) is reported to be present in similar to 2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence in situ hybridization analyses-in a three-step manner-using probes for: (i) CDKN2A at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87; P = 0.002) and high hyperdiploidy (0.82; P = 0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gauffin, F.Karolinska Institutet (author)
  • Kuchinskaya, E.Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (author)
  • Heyman, M.Karolinska Institutet (author)
  • Schoumans, J.Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (author)
  • Blennow, E.Karolinska Institutet (author)
  • Gustafsson, B.Karolinska Institutet (author)
  • Barbany, G. (author)
  • Golovleva, IrinaUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)irgo0001 (author)
  • Ehrencrona, HansLund University,Lunds universitet,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:lu)med-hen (author)
  • Cavelier, LuciaUppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)lucicava (author)
  • Palmqvist, LindaLund University,Lunds universitet,Socialmedicin och global hälsa,Forskargrupper vid Lunds universitet,Social Medicine and Global Health,Lund University Research Groups,Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:lu)med-lip (author)
  • Lönnerholm, GudmarUppsala universitet,Institutionen för kvinnors och barns hälsa,Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden(Swepub:uu)gudmarlh (author)
  • Nordenskjöld, M.Karolinska Institutet (author)
  • Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden(Swepub:lu)kgen-bjo (author)
  • Forestier, ErikUmeå universitet,Pediatrik(Swepub:umu)erfo0007 (author)
  • Nordgren, A.Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (author)
  • Karolinska InstitutetDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

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  • In:LeukemiaLondon : Springer Science and Business Media LLC25:4, s. 622-6280887-69241476-5551

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