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FOXP3 and survival ...
FOXP3 and survival in urinary bladder cancer
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- Winerdal, Malin E (author)
- Karolinska Institutet
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- Marits, Per (author)
- Karolinska Institutet
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Winerdal, Max (author)
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- Hasan, Mudhar (author)
- Karolinska Institutet
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- Rosenblatt, Robert (author)
- Karolinska Institutet
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- Tolf, Anna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Alafuzoff
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Selling, Katarina (author)
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- Sherif, Amir (author)
- Karolinska Institutet
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- Winqvist, Ola (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: BJU International. - 1464-4096 .- 1464-410X. ; 108:10, s. 1672-1678
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE:To investigate the possible impact of FOXP3 expression in T-cells, as well as in tumour cells, on long-term survival in patients with urinary bladder cancer (UBC) invading muscle.PATIENTS AND METHODS:In a retrospective study, tumour specimens from 37 patients cystectomized for T1-T4 UBC during 1999-2002 at the Karolinska University Hospital were examined by immunohistochemistry for tumour expression and/or infiltration of immune cells expressing FOXP3 as well as CD3. The results obtained were correlated with clinicopathological parameters, where the primary and secondary outcomes investigated were overall survival and progression-free survival, respectively.RESULTS:Infiltration of CD3(+) and FOXP3(+) lymphocytes (≥3 cells per high-power field) were both correlated with better survival, and this relationship persisted throughout the whole study period (all P < 0.05). Patients with FOXP3(+) tumour cells had decreased long-term survival compared to those patients with FOXP3(-) tumours (P < 0.05). Despite a limited amount of patient material, the results of the present study indicate that FOXP3 expression, in both lymphocytes and tumour cells, is an important prognostic factor in UBC.CONCLUSIONS:FOXP3 expression in UBC cells is associated with decreased long-term survival and thus may be a novel negative prognostic factor in UBC invading muscle. By contrast, the presence of FOXP3(+) tumour-infiltrating lymphocytes was correlated with a positive prognosis. Because FOXP3 is up-regulated upon activation in human T-cells, FOXP3 may serve more as an activation marker than as a regulatory T-cell indicator in this case. These results support the need for larger prospective studies aiming to confirm the results obtained and to examine the underlying mechanisms in detail.
Keyword
- Urology and andrology
- Urologi och andrologi
- Urologi
- Urology
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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