The Prognostic Role of the STK15 T91A Polymorphism and of STK15 mRNA Expression in Patients with Urothelial Cell Carcinoma

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Fältnamn	Indikatorer	Metadata
000		02861naa a2200421 4500
001		oai:DiVA.org:uu-15356
003		SwePub
008		080211s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153562 URI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Schultz, Iman J.4 aut
245	1 0	a The Prognostic Role of the STK15 T91A Polymorphism and of STK15 mRNA Expression in Patients with Urothelial Cell Carcinoma
264	1	c 2007
338		a print2 rdacarrier
520		a Background: The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression was investigated in patients with urothelial cell carcinoma (UCC). Materials and Methods: The STK15 genotype with respect to the T91A polymorphism was assessed by restriction fragment length polymorphism in 135 patients. STK15 mRNA expression was measured in tumor tissues of 103 patients, using real-time quantitative PCR. Results: The T91A polymorphism lacked any prognostic information in our patient cohort. Interestingly though, STK15 mRNA expression was increased in invasive and high-grade tumors (p-values of 0.009 and 0.0001, respectively). Additionally, patients with superficial UCC (n=82) who had a tumor recurrence in the first year after surgery displayed elevated STK15 mRNA expression levels (p=0.009). Kaplan-Meier survival analysis revealed an increased risk of tumor progression for patients with Ta tumors (n=62) and high STK15 expression (log-rank p=0.04). Furthermore, a decreased overall (log-rank p=0.006) and UCC-specific survival (log-rank p=0.001) were shown for patients with elevated STK15 mRNA levels. Conclusion: Patients with UCC and elevated levels of STK15 mRNA generally showed a more adverse disease course than patients with low levels. This may help in identifying patients in need of more aggressive treatment.
653		a Urothelial cell carcinoma
653		a STK15
653		a T91A polymorphism
653		a mRNA expression
653		a prognosis
653		a MEDICINE
653		a MEDICIN
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a Roelofs, Rian4 aut
700	1	a Van Aarssen, Yvonne4 aut
700	1	a Babjuk, Marko4 aut
700	1	a Willems, Johannes L.4 aut
700	1	a Malmström, Per-Unou Uppsala universitet,Institutionen för kirurgiska vetenskaper,Urologi4 aut0 (Swepub:uu)perunoms
700	1	a Swinkels, Dorine W.4 aut
700	1	a Witjes, J. Alfred4 aut
700	1	a De Kok, Jacques B.4 aut
710	2	a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org
773	0	t Anticancer Researchg 27:2, s. 1025-1030q 27:2<1025-1030x 0250-7005x 1791-7530
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15356

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By the author/editor: Schultz, Iman J.; Kiemeney, Lamber ...; Roelofs, Rian; Van Aarssen, Yvo ...; Babjuk, Marko; Willems, Johanne ...; show more...; Malmström, Per-U ...; Swinkels, Dorine ...; Witjes, J. Alfre ...; De Kok, Jacques ...; show less...

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