Sökning: onr:"swepub:oai:DiVA.org:uu-154292" > TAR-DNA binding pro...
Fältnamn | Indikatorer | Metadata |
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000 | 03503naa a2200577 4500 | |
001 | oai:DiVA.org:uu-154292 | |
003 | SwePub | |
008 | 110530s2011 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:a9bd3781-fea7-4253-991b-746e3617176f | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1542922 URI |
024 | 7 | a https://doi.org/10.1007/s00702-010-0574-52 DOI |
024 | 7 | a https://lup.lub.lu.se/record/19867992 URI |
040 | a (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rauramaa, Tuomas4 aut |
245 | 1 0 | a TAR-DNA binding protein-43 and alterations in the hippocampus |
264 | c 2011-01-06 | |
264 | 1 | b Springer Science and Business Media LLC,c 2011 |
338 | a print2 rdacarrier | |
520 | a Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a TAR-DNA binding protein-43 | |
653 | a Hyperphosphorylated-tau | |
653 | a p62 | |
653 | a Immunohistochemistry | |
653 | a Post-mortem | |
653 | a Hippocampal alterations | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a TAR-DNA binding protein-43 | |
653 | a Hyperphosphorylated-tau | |
653 | a p62 | |
653 | a Immunohistochemistry | |
653 | a Post-mortem | |
653 | a Hippocampal alterations | |
700 | 1 | a Pikkarainen, Maria4 aut |
700 | 1 | a Englund, Elisabetu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-een |
700 | 1 | a Ince, Paul G.4 aut |
700 | 1 | a Jellinger, Kurt4 aut |
700 | 1 | a Paetau, Anders4 aut |
700 | 1 | a Alafuzoff, Irinau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Alafuzoff4 aut0 (Swepub:uu)irial548 |
710 | 2 | a Tumörmikromiljöb Sektion I4 org |
773 | 0 | t Journal of neural transmissiond : Springer Science and Business Media LLCg 118:5, s. 683-689q 118:5<683-689x 0300-9564x 1435-1463 |
856 | 4 | u http://dx.doi.org/10.1007/s00702-010-0574-5y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154292 |
856 | 4 8 | u https://doi.org/10.1007/s00702-010-0574-5 |
856 | 4 8 | u https://lup.lub.lu.se/record/1986799 |
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