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PROX1 is a predicto...
PROX1 is a predictor of survival for gliomas WHO grade II
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- Elsir, T. (author)
- Karolinska Institutet
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- Qu, M. (author)
- Uppsala universitet,Neurologi
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- Berntsson, Shala G. (author)
- Uppsala universitet,Neurologi
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Orrego, A. (author)
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Olofsson, T. (author)
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- Lindström, M. S. (author)
- Karolinska Institutet
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- Nistér, M. (author)
- Karolinska Institutet
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von Deimling, A. (author)
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Hartmann, C. (author)
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- Ribom, Dan (author)
- Uppsala universitet,Neurologi
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- Smits, Anja (author)
- Uppsala universitet,Neurologi
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(creator_code:org_t)
- 2011-05-10
- 2011
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 104:11, s. 1747-1754
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Abstract
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- Background:The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcription factor that has a critical role in the development of various organs. PROX1 has been ascribed both oncogenic and tumour suppressive functions in human cancers. We have recently shown that PROX1 may act as a diagnostic marker for high-grade gliomas. The aim of this study was to address the prognostic value of PROX1 in grade II gliomas.Methods:A total of 116 samples were evaluated for the presence of PROX1 protein. The number of immunopositive cells was used as a variable in survival analysis, together with established prognostic factors for this patient group.Results:Higher PROX1 protein was associated with poor outcome. In the multivariate analysis, PROX1 was identified as an independent factor for survival (P=0.024), together with the presence of mutated isocitrate dehydrogenase 1 R132H protein, and with combined losses of chromosomal arms 1p/19q in oligodendrocytic tumours.Conclusion:PROX1 is a novel predictor of survival for grade II gliomas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- low-grade glioma
- astrocytoma
- oligodendroglioma
- PROX1
- prognosis
- survival
- Neurology
- Neurologi
- Neurology
- Neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Elsir, T.
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Qu, M.
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Berntsson, Shala ...
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Orrego, A.
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Olofsson, T.
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Lindström, M. S.
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show more...
-
Nistér, M.
-
von Deimling, A.
-
Hartmann, C.
-
Ribom, Dan
-
Smits, Anja
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Karolinska Institutet