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Fetal, Developmenta...
Fetal, Developmental, and Parental Influences on Cystatin C in Childhood : The Uppsala Family Study
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Nitsch, Dorothea (author)
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- Sandling, Johanna K. (author)
- Uppsala universitet,Molekylär medicin
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- Byberg, Liisa (author)
- Uppsala universitet,Ortopedi
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Tuvemo, Torsten (author)
- Uppsala universitet,Pediatrik
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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- Koupil, Ilona (author)
- Stockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS)
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Leon, David A. (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: American Journal of Kidney Diseases. - : Elsevier BV. - 0272-6386 .- 1523-6838. ; 57:6, s. 863-872
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Background: The aim was to identify determinants (biomedical and social characteristics of children and their parents) of cystatin C levels in healthy children drawn from a population sample. Study Design: Cross-sectional study. Setting & Participants: 425 pairs of consecutive full siblings born 1987-1995 in Uppsala were identified using the Swedish Medical Birth Registry and invited with their parents for examination in 2000-2001. Outcome: Serum cystatin C level was log-transformed and analyzed using random-effects models. Measurements: The examination in parents and children consisted of a nonfasting blood sample, anthropometry, and questionnaires about lifestyle and socioeconomic position. Tanner stage was used for assessment of pubertal status. Results: In age-, height-, and body mass index-adjusted analyses, cystatin C level increased by 2.6% (95% CI, 0.3%-4.8%) higher in Tanner stage 2 vs 1 girls, and 1.6% (95% CI, 0.2%-3.1%) lower in boys than girls. For every 10% increase in maternal cystatin C level, offspring cystatin C level increased by 3.0% (95% CI, 2.2%-3.8%); the equivalent effect for paternal cystatin C level was 2.1% (95% CI, 1.3%-2.9%). Lower maternal education was associated with a 2.4% (95% CI, 0.3%-4.6%) higher cystatin C level in their offspring. Limitations: Cross-sectional study design, missing cystatin C values for subset of parents, lack of urinary measurements, no gold-standard measurement of glomerular filtration rate. Conclusions: There are intergenerational associations of cystatin C level in families in line with previous reports of heritability of kidney disease. Lower maternal education is associated with higher cystatin C levels in their children. Further studies of healthy children are needed to explore the biological mechanisms for these findings. If cystatin C is measured, these studies will need to record pubertal stages.
Keyword
- Birth weight
- children
- cystatin C
- family study
- intergenerational association
- puberty
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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