Search: onr:"swepub:oai:DiVA.org:uu-155249" >
Are blood pressure ...
Are blood pressure and diabetes additive or synergistic risk factors? : outcome in 8494 subjects randomly recruited from 10 populations
-
Sehestedt, Thomas (author)
-
Hansen, Tine W. (author)
-
Li, Yan (author)
-
show more...
-
Richart, Tom (author)
-
Boggia, Jose (author)
-
Kikuya, Masahiro (author)
-
Thijs, Lutgarde (author)
-
Stolarz-Skrzypek, Katarzyna (author)
-
Casiglia, Edoardo (author)
-
Tikhonoff, Valerie (author)
-
Malyutina, Sofia (author)
-
Nikitin, Yuri (author)
-
- Björklund-Bodegård, Kristina (author)
- Uppsala universitet,Geriatrik
-
Kuznetsova, Tatiana (author)
-
Ohkubo, Takayoshi (author)
-
- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
Torp-Pedersen, Christian (author)
-
Jeppesen, Jorgen (author)
-
Ibsen, Hans (author)
-
Imai, Yutaka (author)
-
Wang, Jiguang (author)
-
Sandoya, Edgardo (author)
-
Kawecka-Jaszcz, Kalina (author)
-
Staessen, Jan A. (author)
-
show less...
-
(creator_code:org_t)
- 2011-02-10
- 2011
- English.
-
In: Hypertension Research. - : Springer Science and Business Media LLC. - 0916-9636 .- 1348-4214. ; 34:6, s. 714-721
- Related links:
-
https://www.nature.c...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- It remains unknown whether diabetes and high blood pressure (BP) are simply additive risk factors for cardiovascular outcome or whether they act synergistically and potentiate one another. We performed 24-h ambulatory BP monitoring in 8494 subjects (mean age, 54.6 years; 47.0% women; 6.9% diabetic patients) enrolled in prospective population studies in 10 countries. In multivariable-adjusted Cox regression, we assessed the additive as opposed to the synergistic effects of BP and diabetes in relation to a composite cardiovascular endpoint by testing the significance of appropriate interaction terms. During 10.6 years (median follow-up), 1066 participants had a cardiovascular complication. Diabetes mellitus as well as the 24-h ambulatory BP were independent and powerful predictors of the composite cardiovascular endpoint. However, there was no synergistic interaction between diabetes and 24-h, daytime, or nighttime, systolic or diastolic ambulatory BP (P for interaction, 0.07 <= P <= 0.97). The only exception was a borderline synergistic effect between diabetes and daytime diastolic BP in relation to the composite cardiovascular endpoint (P=0.04). In diabetic patients, with normotension as the reference group, the adjusted hazard ratios for the cardiovascular endpoint were 1.35 (95% confidence interval (CI), 0.87-2.11) for white-coat hypertension, 1.78 (95% CI, 1.22-2.60) for masked hypertension and 2.44 (95% CI, 1.92-3.11) for sustained hypertension. The hazard ratios for non-diabetic subjects were not different from those of diabetic patients (P-values for interaction, 0.09 <= P <= 0.72). In conclusion, in a large international population-based database, both diabetes mellitus and BP contributed equally to the risk of cardiovascular complications without evidence for a synergistic effect. Hypertension Research (2011) 34, 714-721; doi:10.1038/hr.2011.6; published online 10 February 2011
Keyword
- ambulatory blood pressure
- cardiovascular risk factors
- diabetes mellitus
- epidemiology
- population science
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sehestedt, Thoma ...
-
Hansen, Tine W.
-
Li, Yan
-
Richart, Tom
-
Boggia, Jose
-
Kikuya, Masahiro
-
show more...
-
Thijs, Lutgarde
-
Stolarz-Skrzypek ...
-
Casiglia, Edoard ...
-
Tikhonoff, Valer ...
-
Malyutina, Sofia
-
Nikitin, Yuri
-
Björklund-Bodegå ...
-
Kuznetsova, Tati ...
-
Ohkubo, Takayosh ...
-
Lind, Lars
-
Torp-Pedersen, C ...
-
Jeppesen, Jorgen
-
Ibsen, Hans
-
Imai, Yutaka
-
Wang, Jiguang
-
Sandoya, Edgardo
-
Kawecka-Jaszcz, ...
-
Staessen, Jan A.
-
show less...
- Articles in the publication
-
Hypertension Res ...
- By the university
-
Uppsala University