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Molecular diagnosti...
Molecular diagnostics using magnetic nanobeads
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- de la Torre, Teresa Zardan Gomez (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Strömberg, Mattias (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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Göransson, Jenny (author)
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- Gunnarsson, Klas (author)
- Uppsala universitet,Fasta tillståndets fysik
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- Nilsson, Mats (author)
- Uppsala universitet,Molekylära verktyg
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- Svedlindh, Peter (author)
- Uppsala universitet,Fasta tillståndets fysik
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- Strømme, Maria (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- 2010-02-15
- 2010
- English.
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Series: Journal of Physics: Conference Series, 1742-6588 ; 200
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In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596.
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In this paper, we investigate the volume-amplified magnetic nanobead detection assay with respect to bead size, bead concentration and bead oligonucleotide surface coverage in order to improve the understanding of the underlying microscopic mechanisms. It has been shown that: (i) the immobilization efficiency of the beads depends on the surface coverage of oligonucleotides, (ii) by using lower amounts of probe-tagged beads, detection sensitivity can be improved and (iii) using small enough beads enables both turn-off and turn-on detection. Finally, biplex detection was demonstrated.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- kon (subject category)
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