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Prognostic signific...
Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-04-05
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Informa UK Limited,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-156016
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156016URI
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https://doi.org/10.3109/00016489.2011.560186DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122764841URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Conclusion: Matrix metalloproteinase (MMP)-20 is overexpressed in laryngeal squamous cell carcinoma (LSCC) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis. Overexpression of MMP-20 may be used as a significant prognostic factor for lymph node metastasis. All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC. Objective: The MMPs are a gene family of zinc-dependent endopeptidases that have been implicated in tumor invasion and metastasis, and MMP-20 is a new member of the MMP family. The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and, if so, the significance of its overexpression in relation to clinical parameters. Methods: We analyzed 33 cases of LSCC with RT-PCR and 73 cases of LSCC with immunohistochemistry compared with normal laryngeal epithelium. Results: We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium.
Subject headings and genre
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Enamelysin
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prognostic evaluation
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Li, Yifan
(author)
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Liu, Zhongmin
(author)
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Zhang, Liyong
(author)
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Anniko, MattiUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)mattanni
(author)
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Duan, MaoliKarolinska Institutet
(author)
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Uppsala universitetÖron-, näs- och halssjukdomar
(creator_code:org_t)
Related titles
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In:Acta Oto-Laryngologica: Informa UK Limited131:7, s. 769-7730001-64891651-2251
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