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Pregnancy and risk ...
Pregnancy and risk of acute myeloid leukaemia : a case-control study
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- Larfors, Gunnar (author)
- Karolinska Institutet,Uppsala universitet,Hematologi
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi
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- Cnattingius, Sven (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2011-07-15
- 2011
- English.
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In: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 87:2, s. 169-171
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Although maternal haematopoiesis is characterised by rapid proliferation and immunological adjustment, leukaemia seldom occurs in pregnant women. In this case-control study, we investigated pregnancy and risk of acute myeloid leukaemia (AML). A total of 785 women with AML diagnosed in ages 15-50 were compared with 1576 age-and sex-matched controls. At the time of diagnosis, 13 cases and 53 controls were pregnant (1.3% and 3.4%, respectively), resulting in a significantly reduced odds ratio of 0.44 (95% confidence interval 0.22-0.85). Odds ratios of AML during the years following childbirth were close to unity. The results suggest that pregnancy conveys a strong short-term protection against AML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- acute myeloid leukaemia
- pregnancy
- case-control study
- risk factor
- maternal
- Haematology
- Hematologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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