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Involvement of endo...
Involvement of endogenous glucagon-like peptide-1 in regulation of gastric motility and pancreatic endocrine secretion
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Witte, Anne-Barbara (author)
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- Gryback, Per (author)
- Karolinska Institutet
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- Jacobsson, Hans (author)
- Karolinska Institutet
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- Naslund, Erik (author)
- Karolinska Institutet
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- Hellström, Per Martin (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Holst, Jens Juul (author)
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Hilsted, Linda (author)
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- Schmidt, Peter Thelin (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2010-11-30
- 2011
- English.
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In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 46:4, s. 428-435
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Objective. To study the role of endogenous glucagon-like peptide-1 (GLP-1) on gastric emptying rates of a solid meal as well as postprandial hormone secretion and glucose disposal. Material and methods. In nine healthy subjects, gastric emptying of a 310-kcal radio-labelled solid meal and plasma concentrations of insulin, glucagon and glucose were measured during infusion of saline or the GLP-1 receptor antagonist exendin(9-39)amide (Ex(9-39)) at 300 pmol·kg−1·min−1. Results. Ex(9-39) infusion had no effect on the total gastric emptying curve, but changed the intra-gastric distribution of the meal. During infusion of Ex(9-39), more content stayed in the upper stomach (79.1 ± 2.5% of total during Ex(9-39) compared to 66.6 ± 5.7% during saline at 5 min). During Ex(9-39) infusion, higher concentrations of plasma glucagon were measured both before (after 40 min of Ex(9-39) infusion the glucagon level was 15.1 ± 0.7 pmol·L−1 compared to 5.4 ± 1.4 during saline) and after the meal, and postprandial GLP-1 levels increased. Basal insulin and glucose levels were not affected by Ex(9-39), but the postprandial rise of insulin and glucose enhanced during Ex(9-39). Conclusions. Endogenous GLP-1 is involved in the regulation of gastric motility in relation to meal intake and also in the regulation of postprandial insulin and glucose levels. Furthermore, endogenous GLP-1 seems to tonically restrain glucagon secretion.
Keyword
- Exendin 9-39
- gastric emptying
- GLP-1
- glucagon
- insulin
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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