Tumour-loaded alpha-type 1-polarized Dendritic Cells from Patients with Chronic Lymphocytic Leukaemia Produce a Superior NK-, NKT- and CD8(+) T Cell-attracting Chemokine Profile

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-158151" > Tumour-loaded alpha...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Gustafsson, Karin (author)

Tumour-loaded alpha-type 1-polarized Dendritic Cells from Patients with Chronic Lymphocytic Leukaemia Produce a Superior NK-, NKT- and CD8(+) T Cell-attracting Chemokine Profile

Article/chapterEnglish2011

Publisher, publication year, extent ...

2011-08-07
Wiley,2011
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-158151
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158151URI
https://doi.org/10.1111/j.1365-3083.2011.02580.xDOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Tumour-loaded dendritic cells (DCs) from patients with chronic lymphocytic leukaemia (CLL) matured using an a-type 1-polarized DC cocktail (IL-1 beta/TNF-alpha/IFN-alpha/IFN-gamma/poly-I:C;alpha DC1) were recently shown to induce more functional CD8(+) T cells against autologous tumour cells in vitro than DCs matured with the 'standard' cocktail (IL-1 beta/TNF-alpha/IL-6/PGE(2);PGE(2)DCs). However, the ability of vaccine DCs to induce a type 1-polarized immune response in vivo probably relies on additional features, including their ability to induce a CXCR3-dependent recruitment of NK cells into vaccine-draining lymph nodes. Moreover, their guiding of rare tumour-specific CD8(+) T cells to sites of DC-CD4(+) T cell interactions by secretion of CCL3 and CCL4 is needed. We therefore analysed the chemokine profile and the lymphocyte-attracting ability in vitro of monocyte-derived PGE(2)DCs and alpha DC1s from patients with CLL. alpha DC1s produced much higher levels of CXCR3 ligands (CXCL9/CXCL10/CXCL11) than PGE(2)DCs. Functional studies further demonstrated that alpha DC1s were superior recruiters of both NK and NKT cells. Moreover, alpha DC1s produced higher levels of CCL3/CCL4 upon CD40 ligation. These findings suggest that functional alpha DC1s, derived from patients with CLL, produce a desirable NK-, NKT- and CD8(+) T cell-attracting chemokine profile which may favour a guided and Th1-deviated priming of CD8(+) T cells, supporting the idea that alpha DC1-based vaccines have a higher immunotherapeutic potential than PGE(2)DCs.

Subject headings and genre

MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Junevik, Katarina (author)
Werlenius, Olle (author)
Holmgren, Sandra (author)
Karlsson-Parra, AlexUppsala universitet,Klinisk immunologi,Knutson(Swepub:uu)aka12694 (author)
Andersson, Per-Ola (author)
Uppsala universitetKlinisk immunologi (creator_code:org_t)

Related titles

In:Scandinavian Journal of Immunology: Wiley74:3, s. 318-3260300-94751365-3083

Internet link

Find in a library

Scandinavian Journal of Immunology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Gustafsson, Kari ...; Junevik, Katarin ...; Werlenius, Olle; Holmgren, Sandra; Karlsson-Parra, ...; Andersson, Per-O ...

Articles in the publication: Scandinavian Jou ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se