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VEGF-B inhibits apo...
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.
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- Li, Yang (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Zhang, Fan (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Nagai, Nobuo (author)
- Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
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- Tang, Zhongshu (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Zhang, Shuihua (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Scotney, Pierre (author)
- CSL Limited, Parkville, Victoria, Australia
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- Lennartsson, Johan (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Zhu, Chaoyong (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Qu, Yi (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Fang, Changge (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Hua, Jianyuan (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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- Matsuo, Osamu (author)
- Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
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- Fong, Guo-Hua (author)
- Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
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- Ding, Hao (author)
- Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
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- Cao, Yihai (author)
- Karolinska Institutet
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- Becker, Kevin G (author)
- TRIAD Technology Center, National Institute on Aging, NIH, Baltimore, Maryland, USA
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- Nash, Andrew (author)
- CSL Limited, Parkville, Victoria, Australia
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- Heldin, Carl-Henrik (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Li, Xuri (author)
- National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland, USA
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 118:3, s. 913-923
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Despite its early discovery and high sequence homology to the other VEGF family members, the biological functions of VEGF-B remain poorly understood. We revealed here a novel function for VEGF-B as a potent inhibitor of apoptosis. Using gene expression profiling of mouse primary aortic smooth muscle cells, and confirming the results by real-time PCR using mouse and rat cell lines, we showed that VEGF-B inhibited the expression of genes encoding the proapoptotic BH3-only proteins and other apoptosis- and cell death-related proteins, including p53 and members of the caspase family, via activation of VEGFR-1. Consistent with this, VEGF-B treatment rescued neurons from apoptosis in the retina and brain in mouse models of ocular neurodegenerative disorders and stroke, respectively. Interestingly, VEGF-B treatment at the dose effective for neuronal survival did not cause retinal neovascularization, suggesting that VEGF-B is the first member of the VEGF family that has a potent antiapoptotic effect while lacking a general angiogenic activity. These findings indicate that VEGF-B may potentially offer a new therapeutic option for the treatment of neurodegenerative diseases.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Yang
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Zhang, Fan
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Nagai, Nobuo
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Tang, Zhongshu
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Zhang, Shuihua
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Scotney, Pierre
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show more...
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Lennartsson, Joh ...
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Zhu, Chaoyong
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Qu, Yi
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Fang, Changge
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Hua, Jianyuan
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Matsuo, Osamu
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Fong, Guo-Hua
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Ding, Hao
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Cao, Yihai
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Becker, Kevin G
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Nash, Andrew
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Heldin, Carl-Hen ...
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Li, Xuri
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- Articles in the publication
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Journal of Clini ...
- By the university
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Uppsala University
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Karolinska Institutet