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Targeted resequenci...
Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection
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Albert, F. W. (author)
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Hodges, E. (author)
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Jensen, J. D. (author)
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- Besnier, Francois (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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Xuan, Z. (author)
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Rooks, M. (author)
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Bhattacharjee, A. (author)
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Brizuela, L. (author)
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Good, J. M. (author)
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Green, R. E. (author)
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Burbano, H. A. (author)
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Plyusnina, I. Z. (author)
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Trut, L. (author)
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- Andersson, Leif (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Schoeneberg, T. (author)
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- Carlborg, Örjan (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish University of Agricultural Sciences, Uppsala, Sweden
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Hannon, G. J. (author)
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- Pääbo, Svante (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
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- 2011-02-09
- 2011
- English.
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In: Heredity. - : Springer Science and Business Media LLC. - 0018-067X .- 1365-2540. ; 107:3, s. 205-214
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The identification of the causative genetic variants in quantitative trait loci (QTL) influencing phenotypic traits is challenging, especially in crosses between outbred strains. We have previously identified several QTL influencing tameness and aggression in a cross between two lines of wild-derived, outbred rats (Rattus norvegicus) selected for their behavior towards humans. Here, we use targeted sequence capture and massively parallel sequencing of all genes in the strongest QTL in the founder animals of the cross. We identify many novel sequence variants, several of which are potentially functionally relevant. The QTL contains several regions where either the tame or the aggressive founders contain no sequence variation, and two regions where alternative haplotypes are fixed between the founders. A re-analysis of the QTL signal showed that the causative site is likely to be fixed among the tame founder animals, but that several causative alleles may segregate among the aggressive founder animals. Using a formal test for the detection of positive selection, we find 10 putative positively selected regions, some of which are close to genes known to influence behavior. Together, these results show that the QTL is probably not caused by a single selected site, but may instead represent the joint effects of several sites that were targets of polygenic selection.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience (hsv//eng)
Keyword
- high-throughput sequencing
- sequence capture
- positive selection
- behavior
- QTL mapping
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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Heredity
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To the university's database
- By the author/editor
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Albert, F. W.
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Hodges, E.
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Jensen, J. D.
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Besnier, Francoi ...
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Xuan, Z.
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Rooks, M.
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show more...
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Bhattacharjee, A ...
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Brizuela, L.
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Good, J. M.
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Green, R. E.
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Burbano, H. A.
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Plyusnina, I. Z.
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Trut, L.
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Andersson, Leif
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Schoeneberg, T.
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Carlborg, Örjan
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Hannon, G. J.
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Pääbo, Svante
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Animal and Dairy ...
- Articles in the publication
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Heredity
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences