SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-159775"
 

Search: onr:"swepub:oai:DiVA.org:uu-159775" > Women with bulimia ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Naessen, SabineKarolinska Institutet (author)

Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Elsevier BV,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-159775
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159775URI
  • https://doi.org/10.3945/ajcn.111.014837DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123245065URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: The eating disorder bulimia nervosa (BN) is characterized by frequent episodes of binge eating, followed regularly by inappropriate compensatory behavior, such as self-induced vomiting. Objective: The current investigation was designed to examine possible alterations in the secretion of the gastrointestinal satiety peptides glucagon-like peptide 1 (GLP-1) and pancreatic polypeptide (PP) in women with BN. Design: Twenty-one women with BN and 17 healthy control subjects of comparable age and BMI were recruited. After fasting overnight, the subjects provided blood samples during ingestion of a standardized meal and self-rated their appetite on a visual analog scale. Fasting and meal-related secretion of the incretin GLP-1 and the meal-related feedback signal PP and insulin and glucose as indicators of the metabolic homeostasis were analyzed. Results: Women with BN had significantly lower fasting and postprandial serum concentrations of GLP-1 (P < 0.01) and PP (P < 0.05) than did the control subjects. Furthermore, both the basal (P < 0.001) and peak (P < 0.05) concentrations of insulin were significantly attenuated in the bulimic subjects, whereas glucose concentrations were normal. As a consequence, the bulimic homeostasis model assessment of insulin index values were also lower (P < 0.001). Conclusions: Women with BN secrete abnormally low amounts of GLP-1 and PP, possibly because of the adaption to large meals in the form of enlarged gastric capacity and reduced muscle tone in the gastric wall. Attenuated secretion of these gastrointestinal satiety peptides may play a role in the maintenance of bulimic behavior.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carlström, Kjell (author)
  • Holst, Jens J. (author)
  • Hellström, Per M.Uppsala universitet,Institutionen för medicinska vetenskaper,Gastroenterologi/Hellström(Swepub:uu)perhe742 (author)
  • Hirschberg, Angelica L.Karolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: Elsevier BV94:4, s. 967-9720002-91651938-3207

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Naessen, Sabine
Carlström, Kjell
Holst, Jens J.
Hellström, Per M ...
Hirschberg, Ange ...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Gastroenterology ...
Articles in the publication
American Journal ...
By the university
Uppsala University
Karolinska Institutet

Search outside SwePub

Wikipedia about the author:
Sabine_Naessen
Naessen, Sabine
en

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view