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Patients with palmo...
Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum
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- Murakami, Masamoto (author)
- Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan
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- Hagforsen, Eva (author)
- Uppsala universitet,Dermatologi och venereologi
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- Morhenn, Vera (author)
- Division of Dermatology, University of California, San Diego, CA, USA
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- Ishida-Yamamoto, Akemi (author)
- Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan
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- Iizuka, Hajime (author)
- Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan
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(creator_code:org_t)
- 2011-07-07
- 2011
- English.
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In: Experimental dermatology. - : Wiley. - 0906-6705 .- 1600-0625. ; 20:10, s. 845-847
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recent findings about the pathogenesis of pustulosis palmaris et plantaris (PPP), also known as palmoplantar pustulosis, suggest that IL-17 expression in the acrosyringium as well as infiltration of IL-17 positive cells, e. g. Langerhans cells may play important roles. However, to date, it has not been established whether circulating IL-17 related cytokines are involved in PPP. We studied the circulating IL-17 related cytokines as well as the mRNA levels in lesional skin. IL-17 related cytokine mRNAs were increased in the PPP lesions compared with the control tissues (five patients vs five controls). The serum levels of TNF-alpha, IL-17, IL-22 and IFN-gamma also were significantly increased in PPP, but not IL-23 and IL-8 (48 patients vs 20 controls). Our findings document that not only the serum IL-17 but also tissue IL-17 are elevated in PPP and may be in the pathogenesis of this disorder.
Keyword
- IL-17
- IL-22
- lesion tissue
- palmoplantar pustulosis
- serum
- Dermatology and Venerology
- Dermatologi och venereologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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