Painless drug delivery through microneedle-based transdermal patches featuring active infusion

Nordquist, Lina, 1977- (author): Uppsala universitet,Integrativ Fysiologi,Nordquist,Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University

(creator_code:org_t)

2008
2008
English.
In: IEEE Transactions on Biomedical Engineering. - 0018-9294 .- 1558-2531. ; 55:3, s. 1063-1071

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Abstract Subject headings

This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration to diabetic rats. Active infusion of insulin at 2 mul/h was compared to passive, diffusion-driven, delivery. Continuous active infusion caused significantly higher insulin concentrations in blood plasma. After a 3-h delivery period, the insulin concentration was five times larger compared to passive delivery. Consistent with insulin concentrations, actively administered insulin resulted in a significant decrease of blood glucose levels. Additionally, insertion and liquid injection was verified on human skin. This study shows the feasibility of a patch-like system with on-board liquid storage and dispensing capability. The proposed device represents a first step towards painless and convenient administration of macromolecular drugs such as insulin or vaccines.

By the author/editor: Roxhed, Niclas; Samel, Björn; Nordquist, Lina, ...; Griss, Patrick; Stemme, Göran

About the subject

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Medical Laborato ...

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