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- Roxhed, NiclasKTH,Mikrosystemteknik (author)
Painless drug delivery through microneedle-based transdermal patches featuring active infusion
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- 2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-16044
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16044URI
- https://doi.org/10.1109/TBME.2007.906492DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-7461URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- QC 20100624
- This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration to diabetic rats. Active infusion of insulin at 2 mul/h was compared to passive, diffusion-driven, delivery. Continuous active infusion caused significantly higher insulin concentrations in blood plasma. After a 3-h delivery period, the insulin concentration was five times larger compared to passive delivery. Consistent with insulin concentrations, actively administered insulin resulted in a significant decrease of blood glucose levels. Additionally, insertion and liquid injection was verified on human skin. This study shows the feasibility of a patch-like system with on-board liquid storage and dispensing capability. The proposed device represents a first step towards painless and convenient administration of macromolecular drugs such as insulin or vaccines.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk laboratorie- och mätteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Medical Engineering Medical Laboratory and Measurements Technologies hsv//eng
- drug delivery
- insulin
- intradermal
- microneedles
- transdermal
- MEDICINE
- MEDICIN
- Medical engineering
Added entries (persons, corporate bodies, meetings, titles ...)
- Samel, BjörnKTH,Mikrosystemteknik(Swepub:kth)u12nzcir (author)
- Nordquist, Lina,1977-Uppsala universitet,Integrativ Fysiologi,Nordquist,Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University(Swepub:uu)linor172 (author)
- Griss, PatrickZühlke Engineering AG, Zurich(Swepub:kth)u1phxkgl (author)
- Stemme, GöranKTH,Mikrosystemteknik(Swepub:kth)u1oyebfq (author)
- KTHMikrosystemteknik (creator_code:org_t)
Related titles
- In:IEEE Transactions on Biomedical Engineering55:3, s. 1063-10710018-92941558-2531
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