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Painless drug deliv...
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Roxhed, NiclasKTH,Mikrosystemteknik
(author)
Painless drug delivery through microneedle-based transdermal patches featuring active infusion
- Article/chapterEnglish2008
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-16044
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16044URI
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https://doi.org/10.1109/TBME.2007.906492DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-7461URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20100624
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This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration to diabetic rats. Active infusion of insulin at 2 mul/h was compared to passive, diffusion-driven, delivery. Continuous active infusion caused significantly higher insulin concentrations in blood plasma. After a 3-h delivery period, the insulin concentration was five times larger compared to passive delivery. Consistent with insulin concentrations, actively administered insulin resulted in a significant decrease of blood glucose levels. Additionally, insertion and liquid injection was verified on human skin. This study shows the feasibility of a patch-like system with on-board liquid storage and dispensing capability. The proposed device represents a first step towards painless and convenient administration of macromolecular drugs such as insulin or vaccines.
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Samel, BjörnKTH,Mikrosystemteknik(Swepub:kth)u12nzcir
(author)
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Nordquist, Lina,1977-Uppsala universitet,Integrativ Fysiologi,Nordquist,Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University(Swepub:uu)linor172
(author)
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Griss, PatrickZühlke Engineering AG, Zurich(Swepub:kth)u1phxkgl
(author)
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Stemme, GöranKTH,Mikrosystemteknik(Swepub:kth)u1oyebfq
(author)
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KTHMikrosystemteknik
(creator_code:org_t)
Related titles
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In:IEEE Transactions on Biomedical Engineering55:3, s. 1063-10710018-92941558-2531
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