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Interobserver and i...
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Suzuki, ChikakoKarolinska Institutet
(author)
Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-04-16
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Informa UK Limited,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-160752
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160752URI
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https://doi.org/10.3109/02841861003705794DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120327431URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Response Evaluation Criteria In Solid Tumors (RECIST) and WHO-criteria are used to evaluate treatment effects in clinical trials. The purpose of this study was to examine interobserver and intraobserver variations in radiological response assessment using these criteria.MATERIAL AND METHODS: Thirty-nine patients were eligible. Each patient's series of CT images were reviewed. Each patient was classified into one of four categories according RECIST and WHO-criteria. To examine interobserver variation, response classifications were independently obtained by two radiologists. One radiologist repeated the procedure on two additional different occasions to examine intraobserver variation. Kappa statistics was applied to examine agreement.RESULTS: Interobserver variation using RECIST and WHO-criteria were 0.53 (95% CI 0.33-0.72) and 0.60 (0.39-0.80), respectively. Response rates (RR) according to RECIST obtained by reader A and reader B were 33% and 21%, respectively. RR according to WHO-criteria obtained by reader A and reader B were 33% and 23% respectively. Intraobserver variation using RECIST and WHO-criteria ranged between 0.76-0.96 and 0.86-0.91, respectively.CONCLUSION: Radiological tumor response evaluation according to RECIST and WHO-criteria are subject to considerable inter- and intraobserver variability. Efforts are necessary to reduce inconsistencies from current response evaluation criteria.
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Torkzad, Michael R.Uppsala universitet,Enheten för radiologi(Swepub:uu)micto583
(author)
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Jacobsson, HansKarolinska Institutet
(author)
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Åström, GunnarUppsala universitet,Enheten för radiologi(Swepub:uu)gunnaras
(author)
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Sundin, AndersKarolinska Institutet,Uppsala universitet,Enheten för radiologi(Swepub:uu)anderssu
(author)
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Hatschek, ThomasKarolinska Institutet
(author)
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Fujii, Hirofumi
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Blomqvist, LennartKarolinska Institutet
(author)
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Karolinska InstitutetEnheten för radiologi
(creator_code:org_t)
Related titles
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In:Acta Oncologica: Informa UK Limited49:4, s. 509-5140284-186X1651-226X
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