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Longitudinal MRI st...
Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder
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Järnum, Hanna (author)
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Eskildsen, Simon F (author)
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Steffensen, Elena G (author)
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Lundbye-Christensen, Søren (author)
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Simonsen, Carsten W (author)
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Thomsen, Ib S (author)
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Fründ, Ernst-Torben (author)
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Théberge, Jean (author)
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Enheten för radiologi
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(creator_code:org_t)
- 2011-09-16
- 2011
- English.
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In: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 124:6, s. 435-446
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To determine whether patients with major depressive disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan. Method: A longitudinal 3.0-Tesla (T) magnetic resonance imaging (MRI) study was carried out with cortical thickness measurements with a surface-based approach, perfusion measurements with three-dimensional (3D) pseudo-continuous arterial spin labeling (pCASL), and spectroscopy (1H-MRS) measurements in the anterior cingulate cortex (ACC) with water as an internal reference adjusted for cerebrospinal fluid content. We examined 23 MDD patients and 26 healthy controls. MDD patients underwent a baseline MRI at inclusion and were invited to a follow-up scan when they were in remission or after a 6-month follow-up period. Results: Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters, a significant decrease in perfusion in the frontal lobes and the ACC in non-remitters compared with healthy controls at baseline and significantly reduced N-acetylaspartate, myo-inositol, and glutamate levels in MDD patients compared with healthy controls at baseline. Conclusion: Using novel MRI techniques, we have found abnormalities in cerebral regions related to cortical-limbic pathways in MDD patients.
Keyword
- major depressive disorder
- longitudinal study
- magnetic resonance imaging
- perfusion
- magnetic resonance spectroscopy
Publication and Content Type
- ref (subject category)
- art (subject category)
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