SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-162827"
 

Search: onr:"swepub:oai:DiVA.org:uu-162827" > Identification of g...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Vaysse, Amaury (author)

Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-10-13
  • Public Library of Science (PLoS),2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-162827
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-162827URI
  • https://doi.org/10.1371/journal.pgen.1002316DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123571434URI
  • https://res.slu.se/id/publ/42865URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test statistics to identify regions under selection in 509 dogs from 46 diverse breeds using a newly developed high-density genotyping array consisting of >170,000 evenly spaced SNPs. We first identify 44 genomic regions exhibiting extreme differentiation across multiple breeds. Genetic variation in these regions correlates with variation in several phenotypic traits that vary between breeds, and we identify novel associations with both morphological and behavioral traits. We next scan the genome for signatures of selective sweeps in single breeds, characterized by long regions of reduced heterozygosity and fixation of extended haplotypes. These scans identify hundreds of regions, including 22 blocks of homozygosity longer than one megabase in certain breeds. Candidate selection loci are strongly enriched for developmental genes. We chose one highly differentiated region, associated with body size and ear morphology, and characterized it using high-throughput sequencing to provide a list of variants that may directly affect these traits. This study provides a catalogue of genomic regions showing extreme reduction in genetic variation or population differentiation in dogs, including many linked to phenotypic variation. The many blocks of reduced haplotype diversity observed across the genome in dog breeds are the result of both selection and genetic drift, but extended blocks of homozygosity on a megabase scale appear to be best explained by selection. Further elucidation of the variants under selection will help to uncover the genetic basis of complex traits and disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ratnakumar, AbhiramiUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)abhra806 (author)
  • Derrien, Thomas (author)
  • Axelsson, ErikUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)eraxe021 (author)
  • Rosengren Pielberg, GerliUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)gepie020 (author)
  • Sigurdsson, Snaevar (author)
  • Fall, Tove,1979-Karolinska Institutet(Swepub:uu)tovfa878 (author)
  • Seppälä, Eija H (author)
  • Hansen, Mark S T (author)
  • Lawley, Cindy T (author)
  • Karlsson, Elinor K (author)
  • Bannasch, Danika (author)
  • Vilà, Carles (author)
  • Lohi, Hannes (author)
  • Galibert, Francis (author)
  • Fredholm, Merete (author)
  • Häggström, JensSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48327 (author)
  • Hedhammar, ÅkeSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)49648 (author)
  • André, Catherine (author)
  • Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America(Swepub:uu)kerli865 (author)
  • Hitte, Christophe (author)
  • Webster, Matthew ThomasUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)maweb226 (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Related titles

  • In:PLOS Genetics: Public Library of Science (PLoS)7:10, s. e1002316-1553-73901553-7404

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view