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Associations betwee...
Associations between ten biological tumor markers in squamous cell cervical cancer and serum estradiol, serum progesterone and smoking
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- Lindström, Annika K. (author)
- Umeå universitet,Uppsala universitet,Centrum för klinisk forskning Dalarna,Onkologi
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- Stendahl, Ulf (author)
- Umeå universitet,Onkologi
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Tot, Tibor (author)
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- Hellberg, Dan (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Centrum för klinisk forskning Dalarna,Obstetrisk forskning/Axelsson
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Anticancer Research. - 0250-7005 .- 1791-7530. ; 27:3B, s. 1401-1406
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Abstract
Subject headings
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- Background and Aim: To study possible associations between selected tumor markers and co-factors in squamous cell cervical cancer. Materials and Methods: Ten biological tumor markers representing different functions in carcinogenesis were diagnosed in 128 cases of squamous cell cervical cancer. These were p53, c-myc, EGFR, COX-2, CD4+, VEGF, E-cadherin, CD44, Ki-67 (MIB-1), and p27. Smoking habits and previous oral contraceptive use were registered. Serum estradiol and progesterone levels were evaluated in 80 women. Each marker was compared to these four variables. Results: Highly significant associaions were found between strong c-myc staining (≥50%) and increased serum progesterone (p=0.01), a low EGFR staining (<20%) and high serum estradiol (p=0.0007), and an absence of p53 staining and smoking (p=0.008). There was a association between the absence of p53 and high serum progesterone (p=0.046). Conclusion: The study supports a role of progesterone as a promoter of cervical cancer and indicates that smoking is associated with tumor development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- c-myc
- Cervical cancer
- Epithelial growth factor receptor
- Estradiol
- p53
- Progesterone
- Smoking
- MEDICINE
- MEDICIN
- Oncology
- onkologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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