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Risk factors for ne...
Risk factors for new-onset cat sensitization among adults : A population-based international cohort study
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Olivieri, Mario (author)
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Zock, Jan-Paul (author)
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Accordini, Simone (author)
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Heinrich, Joachim (author)
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Jarvis, Deborah (author)
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Künzli, Nino (author)
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Antó, Josep M (author)
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- Norbäck, Dan (author)
- Uppsala universitet,Arbets- och miljömedicin,Eva Vingård
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Svanes, Cecilie (author)
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Verlato, Giuseppe (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 129:2, s. 420-425
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Cat exposure during childhood has been shown to increase the risk of developing cat sensitization, while the effect of cat exposure in adulthood has not yet been established. OBJECTIVE: To evaluate new-onset sensitization to cat in adulthood in relation to changes in cat keeping. METHODS: A total of 6292 European Community Respiratory Health Survey I (ECRHS I) participants aged 20 to 44 years from 28 European centers, who were not sensitized to cat, were reevaluated 9 years later in ECRHS II. Present and past cat ownership and total and specific IgE levels were assessed in both surveys. Allergen-specific sensitization was defined as a specific serum IgE level of 0.35 kU/L or more. RESULTS: A total of 4468 subjects did not have a cat in ECRHS I or ECRHS II, 473 had a cat only at baseline, 651 acquired a cat during the follow-up, and 700 had a cat at both evaluations. Two hundred thirty-one subjects (3.7%) became sensitized to cat. In a 2-level multivariable Poisson regression model, cat acquisition during follow-up was significantly associated with new-onset cat sensitization (relative risk = 1.85, 95% CI 1.23-2.78) when compared with those without a cat at both surveys. Preexisting sensitization to other allergens, a history of asthma, nasal allergies and eczema, and high total IgE level were also significant risk factors for developing cat sensitization, while cat ownership in childhood was a significant protective factor. CONCLUSION: Our data support that acquiring a cat in adulthood nearly doubles the risk of developing cat sensitization. Hence, cat avoidance should be considered in adults, especially in those sensitized to other allergens and reporting a history of allergic diseases.
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- By the author/editor
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Olivieri, Mario
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Zock, Jan-Paul
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Accordini, Simon ...
-
Heinrich, Joachi ...
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Jarvis, Deborah
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Künzli, Nino
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show more...
-
Antó, Josep M
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Norbäck, Dan
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Svanes, Cecilie
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Verlato, Giusepp ...
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show less...
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Journal of Aller ...
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Uppsala University