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Physiologic respons...
Physiologic responses and plasma endothelin-1 concentrations associated with abrupt cessation of nitric oxide inhalation in isoflurane-anesthetized horses
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Grubb, Tamara L (author)
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- Högman, Marieann (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Integrativ Fysiologi
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Edner, Anna (author)
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Frendin, Jan H M (author)
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Heinonen, Erkki (author)
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Malavasi, Laís M (author)
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- Frostell, Claes G (author)
- Karolinska Institutet
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Ryden, Anneli (author)
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Alving, Kjell (author)
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- Nyman, Görel C (author)
- Uppsala universitet,Klinisk fysiologi
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(creator_code:org_t)
- American Veterinary Medical Association (AVMA), 2008
- 2008
- English.
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In: American Journal of Veterinary Research. - : American Veterinary Medical Association (AVMA). - 0002-9645 .- 1943-5681. ; 69:3, s. 423-430
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- OBJECTIVE: To assess physiologic responses and plasma endothelin (ET)-1 concentrations associated with abrupt cessation of nitric oxide (NO) inhalation in isoflurane-anesthetized horses. ANIMALS: 6 healthy adult Standardbreds. PROCEDURES: Horses were anesthetized with isoflurane in oxygen and placed in dorsal recumbency. Nitric oxide was pulsed into the respiratory tract for 2.5 hours, and then administration was abruptly discontinued. Just prior to commencement and at cessation of NO administration, and at intervals during a 30-minute period following cessation of NO inhalation, several variables including PaO(2), mean pulmonary artery pressure, venous admixture or pulmonary shunt fraction (Qs/Qt), and plasma ET-1 concentration were recorded or calculated. RESULTS: After cessation of NO inhalation, PaO(2) decreased slowly but significantly (172.7 +/- 29.8 mm Hg to 84.6 +/- 10.9 mm Hg) and Qs/Qt increased slowly but significantly (25 +/- 2% to 40 +/- 3%) over a 30-minute period. Mean pulmonary artery pressure increased slightly (14.0 +/- 1.3 mm Hg to 16.8 +/- 1 mm Hg) over the same time period. No change in serum ET-1 concentration was detected, and other variables did not change or underwent minor changes. CONCLUSIONS AND CLINICAL RELEVANCE: The improvement in arterial oxygenation during pulsed inhalation of NO to healthy isoflurane-anesthetized horses decreased only gradually during a 30-minute period following cessation of NO inhalation, and serum ET-1 concentration was not affected. Because a rapid rebound response did not develop, inhalation of NO might be clinically useful in the treatment of hypoxemia in healthy isoflurane-anesthetized horses.
Keyword
- Administration; Inhalation
- Anesthesia; Inhalation/*veterinary
- Animals
- Blood Gas Analysis/veterinary
- Blood Pressure/drug effects
- Bronchodilator Agents/*administration & dosage
- Endothelin-1/*blood
- Female
- Heart Rate/drug effects
- Horses/blood/*physiology
- Male
- Nitric Oxide/*administration & dosage
- Respiration/drug effects
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Grubb, Tamara L
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Högman, Marieann
-
Edner, Anna
-
Frendin, Jan H M
-
Heinonen, Erkki
-
Malavasi, Laís M
-
show more...
-
Frostell, Claes ...
-
Ryden, Anneli
-
Alving, Kjell
-
Nyman, Görel C
-
show less...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet