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The endogenous opio...
The endogenous opioid system in human alcoholics : molecular adaptations in brain areas involved in cognitive control of addiction
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- Bazov, Igor (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden
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- Kononenko, Olga (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden; Bogomoletz Institute of Physiology, Kiev, Ukrain
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- Watanabe, Hiroyuki (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden
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- Kuntić, Vesna (author)
- University of Belgrade, Belgrade, Serbia
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- Sarkisyan, Daniil (author)
- Financial University under the Government of the Russian Federation, Moscow, Russian Federation
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- Taqi, Malik Mumtaz (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden
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- Hussain, Muhammad Zubair (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden
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- Nyberg, Fred (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Yakovleva, Tatjana (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular neuropsychopharmacology,Uppsala University, Uppsala, Sweden
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2011-09-28
- 2013
- English.
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In: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 18:1, s. 161-169
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https://doi.org/10.1...
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Abstract
Subject headings
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- The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to the initiation and maintenance of addiction. Here we evaluated whether the EOS is altered in brain areas involved in cognitive control of addiction including the dorsolateral prefrontal cortex (dl-PFC), orbitofrontal cortex (OFC) and hippocampus in human alcohol-dependent subjects. Levels of EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls. Prodynorphin mRNA and dynorphins in dl-PFC, κ-opioid receptor mRNA in OFC and dynorphins in hippocampus were up-regulated in alcoholics. No significant changes in expression of proenkephalin, and µ- and δ-opioid receptors were evident; pro-opiomelanocortin mRNA levels were below the detection limit. Activation of the κ-opioid receptor by up-regulated dynorphins in alcoholics may underlie in part neurocognitive dysfunctions relevant for addiction and disrupted inhibitory control.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alcohol dependence
- dynorphin
- endogenous opioid system
- human brain
- κ-opioid receptor
- prodynorphin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bazov, Igor
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Kononenko, Olga
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Watanabe, Hiroyu ...
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Kuntić, Vesna
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Sarkisyan, Danii ...
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Taqi, Malik Mumt ...
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show more...
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Hussain, Muhamma ...
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Nyberg, Fred
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Yakovleva, Tatja ...
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Bakalkin, Georgy
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Addiction Biolog ...
- By the university
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Uppsala University
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Örebro University