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[11C]-PIB imaging in patients with Parkinson's disease : preliminary results
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- Johansson, Anders (author)
- Uppsala universitet,Neurologi
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- Savitcheva, Irina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Forsberg, Anders (author)
- Karolinska Institutet
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- Långström, Bengt (author)
- Nordberg, Agneta (author)
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- (creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
- In: Parkinsonism & Related Disorders. - : Elsevier BV. - 1353-8020 .- 1873-5126. ; 14:4, s. 345-347
- Journal article (peer-reviewed)
Abstract
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- [11C]-PIB positron emission tomography ([11C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-β deposition is common in Parkinson's disease (PD) and α-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [11C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [11C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.
Keyword
- Parkinson's disease
- PET
- PIB
- Amyloid
- Lewy bodies
- α-Synuclein
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- ref (subject category)
- art (subject category)
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