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- Singh, A K (author)
CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3-secretion
- Article/chapterEnglish2008
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- Wiley,2008
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- LIBRIS-ID:oai:DiVA.org:uu-16903
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16903URI
- https://doi.org/10.1111/j.1748-1716.2008.01854.xDOI
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- Language:English
- Summary in:English
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- Background and aims: We investigated the role of the recently discovered, villous-expressed anion exchanger Slc26a6 (PAT1) and the predominantly crypt-expressed cystic fibrosis transmembrane regulator (CFTR) in basal and acid-stimulated murine duodenal HCO3− secretion in vivo, and the influence of blood HCO3− concentration on both.Methods: The proximal duodenum of anaesthetized mice was perfused in situ, and HCO3− secretion was determined by back-titration. Duodenal mucosal permeability was assessed by determining 51Cr-EDTA leakage from blood to lumen.Results: Compared with wild type (WT) littermates basal duodenal HCO3− secretory rates were slightly reduced in Slc26-deficient mice at low (∼21 mm), and markedly reduced at high blood HCO3− concentration (∼29 mm). In contrast, basal HCO3− secretion was markedly reduced in CFTR-deficient mice compared with WT littermates both at high and low blood HCO3− concentration. A short-term application of luminal acid increased duodenal HCO3− secretory rate in Slc26a6-deficient and WT mice to the same degree, but had no stimulatory effect in the absence of CFTR. Luminal acidification to pH 2.5 did not alter duodenal permeability.Conclusions: The involvement of Slc26a6 in basal HCO3− secretion in murine duodenum in vivo is critically dependent on the systemic acid/base status, and this transporter is not involved in acid-stimulated HCO3− secretion. The presence of CFTR is essential for basal and acid-induced HCO3− secretion irrespective of acid/base status. This suggests a coupled action of Slc26a6 with CFTR for murine basal duodenal HCO3− secretion, but not acid-stimulated secretion, in vivo.
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- Sjöblom, MarkusDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany(Swepub:uu)msj20812 (author)
- Zheng, W (author)
- Krabbenhöft, A (author)
- Riederer, B (author)
- Rausch, B (author)
- Manns, M P (author)
- Soleimani, M (author)
- Seidler, U (author)
- Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany (creator_code:org_t)
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- In:Acta Physiologica: Wiley193:4, s. 357-3651748-17081748-1716
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