SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-169476"
 

Search: onr:"swepub:oai:DiVA.org:uu-169476" > Hearing preservatio...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Hearing preservation and nanotechnology-based targted drug delivry future in cochlear implantation?

Rask-Andersen, Helge (author)
Uppsala universitet,Öron-, näs- och halssjukdomar
Wei, Liu (author)
Uppsala universitet,Öron-, näs- och halssjukdomar
Bostrom, Marja (author)
Uppsala universitet,Öron-, näs- och halssjukdomar
show more...
Linthicum, Fred (author)
show less...
 (creator_code:org_t)
2009
2009
English.
In: Otology Japan. - 1884-1457. ; 19:5, s. 687-697
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Cochlear Implantation (CI) remains as one of the greatest medical achievements in modern medicine. New and innovative strategies continue to be developed to optimize and improve the functional results of CI surgery. Preservation of residual hearing through a-traumatic surgical techniques and electrode arrays may alter indications. Conditions with profound SNHL with preserved low tone hearing may have several causes and pathology may vary accordingly. In patients with progressive adult-onset SNHL neurons may be conserved even after long duration of deafness. IHCs and OHCs, supporting cells, ganglion cells and dendrites may be preserved in the apical region while in the lower turn despite atrophic organ of Corti and loss of lamina fibers ganglion cells can be present even after 28 years duration of deafness. These spiral ganglion cells may be excellent targets for electric stimulation using EAS technique that combines electric and acoustic stimulation in the same ear and utilizes both low frequency acoustic hearing and electric stimulation of preserved neurons. At the moment we are trying to elucidate the mechanism responsible for this preservation in humans and to use this knowledge for future therapy. Nano-technology may offer new possibilities for focused release of drugs and possibly genes to the inner ear. European project“NanoEar”is a concerted action to develop 3rd generation of nanoparticles (NP) for treatment of inner ear deafness. One goal is to target drugs and genes to specific inner ear cells through so-called multifunctional NP which are degradable, non-toxic, traceable and can be released in a controlled and biocompatible way. The small size of the NP may give new properties for technical advancement but risks must also be thoroughly evaluated. Uppsala is a Swedish partner to evaluate NP uptake in vitro in both human and animal spiral ganglion neurons. In my presentation I will show the system of culture spiral ganglion cells and demonstrate their locomotive behaviour and NP intracellular uptake using time lapse video recording and combined immunofluorescence and confocal microscopy.

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Rask-Andersen, H ...
Wei, Liu
Bostrom, Marja
Linthicum, Fred
Articles in the publication
Otology Japan
By the university
Uppsala University

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view