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U-2973, a novel B-c...
U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner
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- Boström, Hans (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Leuchowius, Karl-Johan (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Hallböök, Helene (author)
- Uppsala universitet,Medicin,Hematologi
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- Nordgren, Ann (author)
- Karolinska Institutet
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- Thörn, Ingrid (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Thorselius, Mia (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Söderberg, Ola (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 81:3, s. 218-225
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- B-cell lymphomas/leukemias with simultaneous t(14;18)(q32;q21) and MYC rearrangements have recently been shown to constitute a separate diagnostic entity, presenting with a rapid clinical course and a very poor prognosis. We describe the establishment of an Epstein-Barr virus negative cell line, designated U-2973, from a male patient with a de novo aggressive B-cell lymphoma/leukemia and very high peripheral blast cell count. Flow cytometry of bone marrow cells and U-2973 displayed a mature B-cell phenotype, and immunostaining showed expression of MYC and BCL2. IG gene rearrangement data were consistent with a lymphoid neoplasm of germinal centre derivation. Cytogenetic studies using conventional G-banding, fluorescent in situ hybridization, spectral karyotyping and single nucleotide polymorphism array demonstrated a complex karyotype with both a t(14;18) and double translocations between MYC and a non-IG gene partner located at chromosome 12p12.1.
Keyword
- t(14;18)
- IGH/BCL2
- MYC
- B-cell
- lymphoma
- leukemia
- cell line
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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