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U-2973, a novel B-c...
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Boström, HansUppsala universitet,Institutionen för genetik och patologi
(author)
U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Wiley,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-16962
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16962URI
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https://doi.org/10.1111/j.1600-0609.2008.01098.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117425037URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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B-cell lymphomas/leukemias with simultaneous t(14;18)(q32;q21) and MYC rearrangements have recently been shown to constitute a separate diagnostic entity, presenting with a rapid clinical course and a very poor prognosis. We describe the establishment of an Epstein-Barr virus negative cell line, designated U-2973, from a male patient with a de novo aggressive B-cell lymphoma/leukemia and very high peripheral blast cell count. Flow cytometry of bone marrow cells and U-2973 displayed a mature B-cell phenotype, and immunostaining showed expression of MYC and BCL2. IG gene rearrangement data were consistent with a lymphoid neoplasm of germinal centre derivation. Cytogenetic studies using conventional G-banding, fluorescent in situ hybridization, spectral karyotyping and single nucleotide polymorphism array demonstrated a complex karyotype with both a t(14;18) and double translocations between MYC and a non-IG gene partner located at chromosome 12p12.1.
Subject headings and genre
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t(14;18)
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IGH/BCL2
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MYC
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B-cell
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lymphoma
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leukemia
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cell line
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Leuchowius, Karl-JohanUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)kaleu839
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Hallböök, HeleneUppsala universitet,Medicin,Hematologi
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Nordgren, AnnKarolinska Institutet
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Thörn, IngridUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)intho172
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Thorselius, MiaUppsala universitet,Institutionen för genetik och patologi
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Rosenquist, RichardUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)richrose
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Söderberg, OlaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)olasoder
(author)
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Sundström, ChristerUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)chrisund
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
Related titles
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In:European Journal of Haematology: Wiley81:3, s. 218-2250902-44411600-0609
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