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  • Boström, HansUppsala universitet,Institutionen för genetik och patologi (author)

U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Wiley,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-16962
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16962URI
  • https://doi.org/10.1111/j.1600-0609.2008.01098.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117425037URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • B-cell lymphomas/leukemias with simultaneous t(14;18)(q32;q21) and MYC rearrangements have recently been shown to constitute a separate diagnostic entity, presenting with a rapid clinical course and a very poor prognosis. We describe the establishment of an Epstein-Barr virus negative cell line, designated U-2973, from a male patient with a de novo aggressive B-cell lymphoma/leukemia and very high peripheral blast cell count. Flow cytometry of bone marrow cells and U-2973 displayed a mature B-cell phenotype, and immunostaining showed expression of MYC and BCL2. IG gene rearrangement data were consistent with a lymphoid neoplasm of germinal centre derivation. Cytogenetic studies using conventional G-banding, fluorescent in situ hybridization, spectral karyotyping and single nucleotide polymorphism array demonstrated a complex karyotype with both a t(14;18) and double translocations between MYC and a non-IG gene partner located at chromosome 12p12.1.

Subject headings and genre

  • t(14;18)
  • IGH/BCL2
  • MYC
  • B-cell
  • lymphoma
  • leukemia
  • cell line
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Leuchowius, Karl-JohanUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)kaleu839 (author)
  • Hallböök, HeleneUppsala universitet,Medicin,Hematologi (author)
  • Nordgren, AnnKarolinska Institutet (author)
  • Thörn, IngridUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)intho172 (author)
  • Thorselius, MiaUppsala universitet,Institutionen för genetik och patologi (author)
  • Rosenquist, RichardUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)richrose (author)
  • Söderberg, OlaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)olasoder (author)
  • Sundström, ChristerUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)chrisund (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:European Journal of Haematology: Wiley81:3, s. 218-2250902-44411600-0609

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