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- Lee, Duk-Hee (author)
Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly : the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2011-07-16
- American Diabetes Association,2011
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- LIBRIS-ID:oai:DiVA.org:uu-169663
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169663URI
- https://doi.org/10.2337/dc10-2116DOI
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- Language:English
- Summary in:English
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- OBJECTIVE: Persistent organic pollutants (POPs), lipophilic chemicals that accumulate mainly in adipose tissue, have recently been linked to type 2 diabetes. However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly.RESEARCH DESIGN AND METHODS: Nineteen POPs (14 polychlorinated biphenyl [PCB] congeners, 3 organochlorine pesticides, 1 brominated diphenyl ether, and 1 dioxin) were measured in plasma collected at baseline in 725 participants, aged 70 years, of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).RESULTS: After adjusting for known type 2 diabetes risk factors, including obesity, odds ratios (ORs) (95% CIs) for type 2 diabetes at age 75 years (n = 36) according to the quintiles of a summary measure of concentrations of PCBs (vs. the lowest quintile) were 4.5, 5.1, 8.8 (1.8-42.7), and 7.5 (1.4-38.8) (P(trend) <0.01). Among organochlorine pesticides, adjusted ORs across concentrations of trans-nonachlor showed that P(trend) = 0.03. Adjusted ORs (95% CIs) across quintiles of the sum of three organochlorine pesticides were 1.1, 1.6, 1.5, and 3.4 (1.0-11.7) (P(trend) = 0.03). Neither brominated diphenyl ether 47 nor dioxin was significantly associated with incident diabetes. The sum of PCBs improved reclassification significantly when added to traditional risk factors for diabetes.CONCLUSIONS: Despite the small number of incident cases, this study found that environmental exposure to some POPs substantially increased risk of future type 2 diabetes in an elderly population.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- spatial memory
- 3D
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- Lind, MonicaUppsala universitet,Arbets- och miljömedicin(Swepub:uu)monilind (author)
- Jacobs, David R (author)
- Salihovic, Samira (author)
- van Bavel, Bert (author)
- Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind (author)
- Uppsala universitetArbets- och miljömedicin (creator_code:org_t)
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- In:Diabetes Care: American Diabetes Association34:8, s. 1778-17840149-59921935-5548
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