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Search: onr:"swepub:oai:DiVA.org:uu-169734" > A comprehensive ana...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005007naa a2200721 4500
001oai:DiVA.org:uu-169734
003SwePub
008120305s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1697342 URI
0247 a https://doi.org/10.1158/1078-0432.CCR-11-22102 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Schmidt, Marcus4 aut
2451 0a A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors
264 1c 2012
338 a print2 rdacarrier
520 a PURPOSE:Although the central role of the immune system for tumor prognosis is generally accepted a single robust marker is not yet available.EXPERIMENTAL DESIGN:Based on ROC (receiver operating characteristic) analyses robust markers were identified from a 60 gene B-cell derived metagene and analyzed in gene expression profiles of 1810 breast cancer, 1056 non-small cell lung cancer, 513 colorectal and 426 ovarian cancer patients. Protein and RNA levels were examined in paraffin embedded tissue of 330 breast cancer patients. The cell types were identified using immunohistochemical co-staining and confocal fluorescence microscopy.RESULTS:We identified immunoglobulin kappa C (IGKC) which as a single marker is similarly predictive and prognostic as the entire B-cell metagene. IGKC was consistently associated with metastasis free survival across different molecular subtypes in node-negative breast cancer (n=965) and predicted response to anthracycline-based neoadjuvant chemotherapy (n=845) [P less than 0.001]. In addition, IGKC gene expression was prognostic in non-small cell lung cancer and colorectal cancer. No association was observed in ovarian cancer. IGKC protein expression was significantly associated with survival in paraffin embedded tissues of 330 breast cancer patients. Tumor infiltrating plasma cells were identified as the source of IGKC expressionCONCLUSION:Our findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer and support concepts to exploit the humoral immune response for anti-cancer therapy. It could be validated in several independent cohorts and performed similarly well in RNA from fresh frozen as well as from paraffin tissue and on protein level by immunostaining.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Patologi
653 a Pathology
7001 a Hellwig, Birte4 aut
7001 a Hammad, Seddik4 aut
7001 a Othman, Amnah4 aut
7001 a Lohr, Miriam4 aut
7001 a Chen, Zonglin4 aut
7001 a Böhm, Daniel4 aut
7001 a Gebhard, Susanne4 aut
7001 a Petry, Ilka Brigitte4 aut
7001 a Lebrecht, Antje4 aut
7001 a Cadenas, Cristina4 aut
7001 a Marchan, Rosemarie4 aut
7001 a Stewart, Joanna4 aut
7001 a Solbach, Christine4 aut
7001 a Holmberg, Larsu Uppsala universitet,Endokrinkirurgi,Regional Oncology Center4 aut0 (Swepub:uu)larsholmb
7001 a Edlund, Karolinau Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)kaedl086
7001 a Göransson Kultima, Hannau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin4 aut0 (Swepub:uu)hagor102
7001 a Rody, Achim4 aut
7001 a Berglund, Andersu Regional Oncology Center4 aut0 (Swepub:uu)andbe182
7001 a Lambe, Matsu Regional Oncology Center4 aut
7001 a Isaksson, Andersu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin4 aut0 (Swepub:uu)andeisak
7001 a Botling, Johanu Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)johanbot
7001 a Karn, Thomas4 aut
7001 a Müller, Volkmar4 aut
7001 a Gerhold-Ay, Aslihan4 aut
7001 a Cotarelo, Christina4 aut
7001 a Sebastian, Martin4 aut
7001 a Kronenwett, Ralf4 aut
7001 a Bojar, Hans4 aut
7001 a Lehr, Hans-Anton4 aut
7001 a Sahin, Ugur4 aut
7001 a Koelbl, Heinz4 aut
7001 a Gehrmann, Mathias4 aut
7001 a Micke, Patricku Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)patmi676
7001 a Rahnenführer, Jörg4 aut
7001 a Hengstler, Jan G4 aut
7102 a Uppsala universitetb Endokrinkirurgi4 org
7730 t Clinical Cancer Researchg 18:9, s. 2695-2703q 18:9<2695-2703x 1078-0432x 1557-3265
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169734
8564 8u https://doi.org/10.1158/1078-0432.CCR-11-2210

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