Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy

Affibody molecules : potential for in vivo imaging of molecular targets for cancer therapy

Tolmachev, Vladimir (author): Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,BMS

Orlova, Anna (author): Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap

Nilsson, Fredrik Y. (author): Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap

Feldwisch, Joachim (author): Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap

Wennborg, Anders (author)

Abrahmsén, Lars (author)

(creator_code:org_t)

2007-03-21
2007
English.
In: Expert Opinion on Biological Therapy. - : Informa Healthcare. - 1471-2598 .- 1744-7682. ; 7:4, s. 555-568

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Targeting radionuclide imaging of tumor-associated antigens may help to select patients who will benefit from a particular biological therapy. Affibody molecules are a novel class of small (approximately 7 kDa) phage display-selected affinity proteins, based on the B-domain scaffold of staphylococcal protein A. A large library (3 x 10(9) variants) has enabled selection of high-affinity (up to 22 pM) binders for a variety of tumor-associated antigens. The small size of Affibody molecules provides rapid tumor localization and fast clearance from nonspecific compartments. Preclinical studies have demonstrated the potential of Affibody molecules for specific and high-contrast radionuclide imaging of HER2 in vivo, and pilot clinical data using indium-111 and gallium-68 labeled anti-HER2 Affibody tracer have confirmed its utility for radionuclide imaging in cancer patients.

By the author/editor: Tolmachev, Vladi ...; Orlova, Anna; Nilsson, Fredrik ...; Feldwisch, Joach ...; Wennborg, Anders; Abrahmsén, Lars

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.