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Increased expressio...
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
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Narkilahti, Susanna (author)
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Jutila, Leena (author)
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- Alafuzoff, Irina (author)
- Department of Neuroscience and Neurology, University of Kuopio Finland
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Karkola, Kari (author)
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Paljärvi, Leo (author)
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Immonen, Arto (author)
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Vapalahti, Matti (author)
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Mervaala, Esa (author)
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Kälviäinen, Reetta (author)
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Pitkänen, Asla (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Neuromolecular medicine. - 1535-1084 .- 1559-1174. ; 9:2, s. 129-44
- Related links:
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https://urn.kb.se/re...
Abstract
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- Temporal lobe epilepsy (TLE) is often caused by a neurodegenerative brain insult that triggers epileptogenesis, and eventually results in spontaneous seizures, i.e., epilepsy. Understanding the mechanisms of cell death is a key for designing new drug therapies for preventing the neurodegeneration associated with TLE. Here, we investigated the expression of caspase 2, a protein involved in programmed cell death, during the course of epilepsy. We investigated caspase 2 expression in hippocampal samples derived from patients operated on for drug refractory TLE. To understand the evolution of altered-caspase 2 expression during the epileptic process, we also examined caspase 2 expression and activity in the rat hippocampus after status epilepticus-induced acute damage, during epileptogenesis, and after the onset of epilepsy. Caspase 2 expression was enhanced in the hippocampal neurons in chronic TLE patients. In rats, status epilepticus-induced caspase 2 labeling paralleled the progression of neurodegeneration. Proteolytic activation and cleavage of caspase 2 was also detected in the rat brain undergoing epileptogenesis. Our data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Narkilahti, Susa ...
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Jutila, Leena
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Alafuzoff, Irina
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Karkola, Kari
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Paljärvi, Leo
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Immonen, Arto
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show more...
-
Vapalahti, Matti
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Mervaala, Esa
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Kälviäinen, Reet ...
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Pitkänen, Asla
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Neuromolecular m ...
- By the university
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Uppsala University