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CSF phosphorylated ...
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.
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Buerger, Katharina (author)
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Ewers, Michael (author)
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Pirttilä, Tuula (author)
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Zinkowski, Raymond (author)
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- Alafuzoff, Irina (author)
- Kuopio University, Finland
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Teipel, Stefan J (author)
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DeBernardis, John (author)
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Kerkman, Daniel (author)
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McCulloch, Cheryl (author)
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Soininen, Hilkka (author)
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Hampel, Harald (author)
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(creator_code:org_t)
- 2006-09-29
- 2006
- English.
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In: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 129:Pt 11, s. 3035-41
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was determined. Concentrations of P-tau231P were measured in frontal cortex homogenates. We found significant correlations between CSF P-tau231P concentrations and scores of NFTs and HP-tau load in all neocortical regions studied. The score of NPs was correlated with CSF P-tau231P only within the frontal cortex. There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Brain
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- By the author/editor
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Buerger, Kathari ...
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Ewers, Michael
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Pirttilä, Tuula
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Zinkowski, Raymo ...
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Alafuzoff, Irina
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Teipel, Stefan J
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show more...
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DeBernardis, Joh ...
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Kerkman, Daniel
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McCulloch, Chery ...
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Soininen, Hilkka
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Hampel, Harald
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Brain
- By the university
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Uppsala University