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Immune modulation b...
Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis
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Zhu, Bing (author)
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Trikudanathan, Subbulaxmi (author)
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Zozulya, Alla L. (author)
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Sandoval-Garcia, Carolina (author)
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Kennedy, Jennifer K. (author)
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Atochina, Olga (author)
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- Norberg, Thomas (author)
- Uppsala universitet,Fysikalisk-organisk kemi,Baltzer
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Castagner, Bastien (author)
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Seeberger, Peter (author)
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Fabry, Zsuzsa (author)
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Harn, Donald (author)
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Khoury, Samia J. (author)
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Guleria, Indira (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Clinical Immunology. - : Elsevier BV. - 1521-6616 .- 1521-7035. ; 142:3, s. 351-361
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Parasitic infections frequently lead to immune deviation or suppression. However, the application of specific parasitic molecules in regulating autoimmune responses remains to be explored. Here we report on the immune modulatory function of Lacto-N-fucopentaose III (LNFPIII), a schistosome glycan, in an animal model for multiple sclerosis. We found that LNFPIII treatment significantly reduced the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation, and skewed peripheral immune response to a Th2 dominant profile. Inflammatory monocytes (IMCs) purified from LNFPIII-treated mice had increased expression of nitric oxide synthase 2, and mediated T cell suppression. LNFPIII treatment also significantly increased mRNA expression of arginase-1, aldehyde dehydrogenase 1 subfamily A2, indoleamine 2,3-dioxygenase and heme oxygenase 1 in splenic IMCs. Furthermore, LNFPIII treatment significantly reduced trafficking of dendritic cells across brain endothelium in vitro. In summary, our study demonstrates that LNFPIII glycan treatment suppresses EAE by modulating both innate and T cell immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Lacto-N-fucopentaose
- Experimental autoimmune encephalomyelitis
- Autoimmune
- Immune modulation
- Klinisk immunologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhu, Bing
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Trikudanathan, S ...
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Zozulya, Alla L.
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Sandoval-Garcia, ...
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Kennedy, Jennife ...
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Atochina, Olga
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show more...
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Norberg, Thomas
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Castagner, Basti ...
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Seeberger, Peter
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Fabry, Zsuzsa
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Harn, Donald
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Khoury, Samia J.
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Guleria, Indira
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Clinical Immunol ...
- By the university
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Uppsala University