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Mental stress impai...
Mental stress impairs endothelial vasodilatory function by a beta-adrenergic mechanism
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- Eriksson, Mats (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Johansson, Kristina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Sarabi, Mahziar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- 2009-07-13
- 2007
- English.
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In: Endothelium. - : Informa UK Limited. - 1062-3329 .- 1029-2373. ; 14:3, s. 151-156
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mental stress has been shown to impair endothelium-dependent vasodilation (EDV) in the human forearm. The aim of this study was to investigate if this response could be blunted by local infusions of beta-blockade (propranolol), alpha-blockade (phentolamine), or neurogenic blockade. Thirty-one young healthy volunteers underwent forearm blood flow (FBF) measurements, using venous occlusion plethysmography, during local intra-arterial infusions of metacholine (MCh; inducing EDV) and sodium nitroprussid (SNP; inducing endothelial-independent vasodilation [EIDV]), respectively. These measurements were repeated during a 5-min mental arithmetic stress test without (n = 8) or with concomitant local infusion of propranolol (n = 7) or phentolamine (n = 8) in the forearm or during axillary plexus blockade (n = 8). An index of endothelial vasodilatory function (EFI) was calculated as the EDV to EIDV ratio. Mental stress impaired EDV significantly (p < .05), and as a result, EFI was significantly reduced (p = .02). This effect on EFI could be blocked by propranolol and neurogenic blockade but not by phentolamine (p < .05). Thus, impairment of endothelial vasodilatory function induced by mental stress could be blocked by beta-adrenergic, but not alpha-adrenergic, receptor blockade.
Keyword
- Beta-Blockade
- Blood Flow
- Endothelium
- Stress
- Vasodilation
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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