Search: onr:"swepub:oai:DiVA.org:uu-173338" > Interleukin-6 recep...
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000 | 10157naa a2201645 4500 | |
001 | oai:DiVA.org:uu-173338 | |
003 | SwePub | |
008 | 120423s2012 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/161399 | |
009 | oai:prod.swepub.kib.ki.se:124310123 | |
009 | oai:DiVA.org:umu-54325 | |
009 | oai:lup.lub.lu.se:9bfa4ba7-9466-4fc2-8d50-562fb12a8893 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1733382 URI |
024 | 7 | a https://doi.org/10.1016/S0140-6736(11)61931-42 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/1613992 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1243101232 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-543252 URI |
024 | 7 | a https://lup.lub.lu.se/record/24946822 URI |
040 | a (SwePub)uud (SwePub)gud (SwePub)kid (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sarwar, Nadeem4 aut |
245 | 1 0 | a Interleukin-6 receptor pathways in coronary heart disease :b a collaborative meta-analysis of 82 studies |
264 | 1 | a New York, NY, USA :b Elsevier,c 2012 |
338 | a print2 rdacarrier | |
520 | a Background: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods: In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125 222 participants. We also compared the frequency of Asp358Ala in 51 441 patients with coronary heart disease and in 136 226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. Findings: The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele >= 0.04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34.3% (95% CI 30.4-38.2) and of interleukin 6 by 14.6% (10.7-18.4), and mean concentration of C-reactive protein was reduced by 7.5% (5.9-9.1) and of fibrinogen by 1.0% (0.7-1.3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3.4% (1.8-5.0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes. Interpretation: Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
700 | 1 | a Butterworth, Adam S.4 aut |
700 | 1 | a Freitag, Daniel F.4 aut |
700 | 1 | a Gregson, John4 aut |
700 | 1 | a Willeit, Peter4 aut |
700 | 1 | a Gorman, Donal N.4 aut |
700 | 1 | a Gao, Pei4 aut |
700 | 1 | a Saleheen, Danish4 aut |
700 | 1 | a Rendon, Augusto4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Chasman, Daniel I.4 aut |
700 | 1 | a Tybjaerg-Hansen, Anneu Karolinska Institutet4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Benjamin, Emelia J.4 aut |
700 | 1 | a Franks, Paul W.u Lunds universitet,Umeå universitet,Medicin,Lund University, Department of Clinical Science, Genetical & Molecular Epidemiology Unit, Malmö, Sweden and Harvard University, School of Public Health, Department of Nutrition, Boston, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Wilde, Arthur A. M.4 aut |
700 | 1 | a Trip, Mieke D.4 aut |
700 | 1 | a Steri, Maristella4 aut |
700 | 1 | a Witteman, Jacqueline C. M.4 aut |
700 | 1 | a Qi, Lu4 aut |
700 | 1 | a van der Schoot, C. Ellen4 aut |
700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
700 | 1 | a Erdmann, Jeanette4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Melzer, David4 aut |
700 | 1 | a Reich, David4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Panagiotakos, Demosthenes B.4 aut |
700 | 1 | a Willeit, Johann4 aut |
700 | 1 | a Wennberg, Patrik4 aut |
700 | 1 | a Woodward, Mark4 aut |
700 | 1 | a Adamovic, Svetlana,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xadasv |
700 | 1 | a Rimm, Eric B.4 aut |
700 | 1 | a Meade, Tom W.4 aut |
700 | 1 | a Gillum, Richard F.4 aut |
700 | 1 | a Shaffer, Jonathan A.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Onat, Altan4 aut |
700 | 1 | a Sundström, Johanu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)johasund |
700 | 1 | a Wassertheil-Smoller, Sylvia4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, School of Public Health and Community Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Gallacher, John4 aut |
700 | 1 | a Cushman, Mary4 aut |
700 | 1 | a Tracy, Russell P.4 aut |
700 | 1 | a Kauhanen, Jussi4 aut |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Salonen, Jukka T.4 aut |
700 | 1 | a Wilhelmsen, Lars4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Cantin, Bernard4 aut |
700 | 1 | a Best, Lyle G.4 aut |
700 | 1 | a Ben-Shlomo, Yoav4 aut |
700 | 1 | a Manson, JoAnn E.4 aut |
700 | 1 | a Davey-Smith, George4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo |
700 | 1 | a Wilson, James F.4 aut |
700 | 1 | a Wilson, Anthony G.4 aut |
700 | 1 | a Assimes, Themistocles L.4 aut |
700 | 1 | a Jansson, John-Olov4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Tivesten, Åsa,d 1969u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xtivas |
700 | 1 | a Ljunggren, Östenu Uppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar4 aut0 (Swepub:uu)osteljun |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a Hamsten, Anders4 aut |
700 | 1 | a Ingelsson, Eriku Karolinska Institutet4 aut |
700 | 1 | a Cambien, Francois4 aut |
700 | 1 | a Hung, Joseph4 aut |
700 | 1 | a Thomas, G. Neil4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Schunkert, Heribert4 aut |
700 | 1 | a Asselbergs, Folkert W.4 aut |
700 | 1 | a Kastelein, John J. P.4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Allin, Kristine H.4 aut |
700 | 1 | a Nordestgaard, Borge G.4 aut |
700 | 1 | a Hopewell, Jemma C.4 aut |
700 | 1 | a Goodall, Alison H.4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a Holm, Hilma4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Ouwehand, Willem H.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Kaptoge, Stephen4 aut |
700 | 1 | a Di Angelantonio, Emanuele4 aut |
700 | 1 | a Harari, Olivier4 aut |
700 | 1 | a Danesh, John4 aut |
710 | 2 | a Karolinska Institutetb Medicin4 org |
773 | 0 | t The Lancetd New York, NY, USA : Elsevierg 379:9822, s. 1205-1213q 379:9822<1205-1213x 0140-6736x 1474-547X |
856 | 4 | u http://dx.doi.org/10.1016/S0140-6736(11)61931-4y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173338 |
856 | 4 8 | u https://doi.org/10.1016/S0140-6736(11)61931-4 |
856 | 4 8 | u https://gup.ub.gu.se/publication/161399 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124310123 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54325 |
856 | 4 8 | u https://lup.lub.lu.se/record/2494682 |
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