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Diurnal Rhythm of C...
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Benedict, ChristianUppsala universitet,Funktionell farmakologi
(author)
Diurnal Rhythm of Circulating Nicotinamide Phosphoribosyltransferase (Nampt/Visfatin/PBEF) : Impact of Sleep Loss and Relation to Glucose Metabolism
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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The Endocrine Society,2012
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LIBRIS-ID:oai:DiVA.org:uu-173826
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173826URI
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https://doi.org/10.1210/jc.2011-2241DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Context Animal studies indicate that nicotinamide phosphoribosyltransferase [Nampt/visfatin/pre-B-cell colony-enhancing factor (PBEF)] contributes to the circadian fine-tuning of metabolic turnover. However, it is unknown whether circulating Nampt concentrations, which are elevated in type 2 diabetes and obesity, display a diurnal rhythm in humans.Objective Our objective was to examine the 24-h profile of serum Nampt in humans under conditions of sleep and sleep deprivation and relate the Nampt pattern to morning postprandial glucose metabolism.InterventionFourteen healthy men participated in two 24-h sessions starting at 1800 h, including either regular 8-h-night sleep or continuous wakefulness. Serum Nampt and leptin were measured in 1.5- to 3-h intervals. In the morning, plasma glucose and serum insulin responses to standardized breakfast intake were determined.Main Outcome Measures Under regular sleep-wake conditions, Nampt levels displayed a pronounced diurnal rhythm, peaking during early afternoon (P < 0.001) that was inverse to leptin profiles peaking in the early night. When subjects stayed awake, the Nampt rhythm was preserved but phase advanced by about 2 h (P < 0.05). Two-hour postprandial plasma glucose concentrations were elevated after sleep loss (P < 0.05), whereas serum insulin was not affected. The relative glucose increase due to sleep loss displayed a positive association with the magnitude of the Nampt phase shift (r = 0.54; P < 0.05).ConclusionsSerum Nampt concentrations follow a diurnal rhythm, peaking in the afternoon. Sleep loss induces a Nampt rhythm phase shift that is positively related to the impairment of postprandial glucose metabolism due to sleep deprivation, suggesting a regulatory impact of Nampt rhythmicity on glucose homeostasis.
Added entries (persons, corporate bodies, meetings, titles ...)
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Shostak, Anton
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Lange, Tanja
(author)
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Brooks, Samantha JUppsala universitet,Funktionell farmakologi(Swepub:uu)sambr210
(author)
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Schiöth, Helgi BUppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
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Schultes, Bernd
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Born, Jan
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Oster, Henrik
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Hallschmid, Manfred
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Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Related titles
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In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society97:2, s. E218-E2220021-972X1945-7197
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