Hematological: Low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study

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Kjellander, ChristianKarolinska Institutet (author)

Hematological : Low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study

Article/chapterEnglish2012

Publisher, publication year, extent ...

2012-03-15
Wiley,2012
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-173964
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173964URI
https://doi.org/10.1111/j.1600-0609.2012.01768.xDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:124386716URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background: Bacteremia is a major cause of morbidity and mortality in patients with hematological malignancies. Objectives: The aim of this study was to define temporal trends in species distribution, antimicrobial susceptibility, and all-cause mortality in bacteremic hospitalized patients receiving no antibacterial prophylaxis during chemotherapy-induced neutropenia. Methods: A total of 677 clinical episodes of bacteremia were identified in 463 patients during 2002-2008, and the results were compared with those published from the same institution during 1980-86 and 1988-2001. No major changes in patient selection were introduced during this period. Results: Between 2002 and 2008, the dominating pathogens were Escherichia coli (18%), coagulase-negative staphylococci (15%), viridans streptococci (14%), Klebsiella spp. (10%), and Enterococcus faecium (8%). The 7-d crude mortality rate was 5.2%. Polymicrobial bacteremia was seen in 25.7% of the patients who died within 7 d and in 13.1% of the survivors (P = 0.04). Acquired resistance was rarely observed, but a statistically significant increase in ciprofloxacin resistance in E. coli was observed. Comparing 2002-2008 with historical data from the same institution, the proportion of Gram-positive isolates remained stable at 53-55% from 1988. Conclusions: The avoidance of fluoroquinolone prophylaxis may have contributed to a stable proportion of Gram-positive bacteremia. The crude mortality was low in an international perspective. Acquired resistance was uncommon, but ciprofloxacin resistance in E. coli increased significantly. We believe that an indiscriminate use of antibacterial prophylaxis could be avoided in neutropenic patients without a negative impact on mortality.

Subject headings and genre

bloodstream infection
hematological malignancy
antimicrobial resistance
hospital epidemiology
polymicrobial bacteremia
temporal trend

Added entries (persons, corporate bodies, meetings, titles ...)

Bjorkholm, MagnusKarolinska Institutet (author)
Cherif, HonarUppsala universitet,Institutionen för medicinska vetenskaper,Hematologi(Swepub:uu)honch489 (author)
Kalin, MatsKarolinska Institutet (author)
Giske, Christian G.Karolinska Institutet (author)
Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:European Journal of Haematology: Wiley88:5, s. 422-4300902-44411600-0609

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