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Genomic imbalances ...
Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma
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- Berglund, Mattias (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen
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- Enblad, Gunilla (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen
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- Thunberg, Ulf (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen
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- Amini, Rose-Marie (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för genetik och patologi
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Roos, Göran (author)
- Umeå universitet,Patologi
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- Erlanson, Martin (author)
- Umeå universitet,Onkologi
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- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Larsson, Catharina (author)
- Karolinska Institutet
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- Lagercrantz, Svetlana (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Modern Pathology. - : Elsevier BV. - 0893-3952 .- 1530-0285. ; 20:1, s. 63-75
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Follicular lymphoma is commonly transformed to a more aggressive diffuse large B-cell lymphoma (DLBCL). In order to molecularely characterize this histiological and clinical transformation, comparative genomic hybridization was applied on 23 follicular lymphoma and 35 transformed DLBCL tumors from a total of 30 patients. The results were also compared with our published findings in de novo DLBCL. Copy number changes were detected in 70% of follicular lymphoma and in 97% of transformed DLBCL. In follicular lymphoma, the most common alterations were +18q21 (33%), +Xq25–26 (28%), +1q31–32 (23%), and -17p (23%), whereas transformed DLBCL most frequently exhibited +Xq25–26 (36%), +12q15 (29%), +7pter-q22 (25%), +8q21 (21%), and -6q16–21(25%). Transformed DLBCL showed significantly more alterations as compared to follicular lymphoma (P=0.0001), and the alterations -6q16–21 and +7pter-q22 were only found in transformed DLBCL but not in follicular lymphoma (P=0.02). Alterations involving +13q22 were significantly less frequent, whereas -4q13–21 was more common in transformed as compared to de novo DLBCL (P=0.01 and P=0.02, respectively). Clinical progression from follicular lymphoma to transformed DLBCL is on the genetic level associated with acquirement of increasing number of genomic copy number changes, with non-random involvement of specific target regions. The findings support diverse genetic background between transformed and de novo DLBCL.
Keyword
- Comparative genomic hybridization
- Lymphoma
- Transformation
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Berglund, Mattia ...
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Enblad, Gunilla
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Thunberg, Ulf
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Amini, Rose-Mari ...
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Sundström, Chris ...
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Roos, Göran
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show more...
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Erlanson, Martin
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Rosenquist, Rich ...
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Larsson, Cathari ...
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Lagercrantz, Sve ...
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show less...
- Articles in the publication
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Modern Pathology
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet